Further evidence of the development of delayed-type autoimmunity against arterial vessel-wall antigens following acute hypertensive damage to arterial vessels in rats.

Acute hypertensive damage to arterial vessels was induced by intravenous injections of hypertension. The in vitro immunological method of the agarose migration technique was used for demonstration of delayed-type autoimmunity against arterial vessel-wall antigens following the damage of the arterial vessels. By means of this technique it was demonstrated that the migration indices from the rats with induced hypertension differed significantly from the control rats, P less than 0.005. This means that an autoimmunity of the delayed type had developed after the hypertensive damage to the arterial vessels. The autoimmunity was tissue specific.