Zheng Daheng, Jin Shikai, Liu Pu-Ste, Ye Jianping, Xie Xin
School of Life and Environmental Sciences, Shaoxing University, Shaoxing, Zhejiang, China.
Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Arch Toxicol. 2024 Oct;98(10):3191-3208. doi: 10.1007/s00204-024-03812-4. Epub 2024 Jul 10.
Ferroptosis is a form of cell death that is induced by iron-mediated accumulation of lipid peroxidation. The involvement of ferroptosis in different pathophysiological conditions has offered new perspectives on potential therapeutic interventions. Natural products, which are widely recognized for their significance in drug discovery and repurposing, have shown great promise in regulating ferroptosis by targeting various ferroptosis players. In this review, we discuss the regulatory mechanisms of ferroptosis and its implications in different pathological conditions. We dissect the interactions between natural products and ferroptosis in cancer, ischemia/reperfusion, neurodegenerative diseases, acute kidney injury, liver injury, and cardiomyopathy, with an emphasis on the relevance of ferroptosis players to disease targetability.
铁死亡是一种由铁介导的脂质过氧化积累所诱导的细胞死亡形式。铁死亡参与不同的病理生理状况为潜在的治疗干预提供了新的视角。天然产物因其在药物发现和重新利用方面的重要性而被广泛认可，已显示出通过靶向各种铁死亡相关因子来调节铁死亡的巨大潜力。在本综述中，我们讨论了铁死亡的调控机制及其在不同病理状况中的意义。我们剖析了天然产物与癌症、缺血/再灌注、神经退行性疾病、急性肾损伤、肝损伤和心肌病中铁死亡之间的相互作用，重点关注铁死亡相关因子与疾病靶向性的相关性。
