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一名慢性淋巴细胞白血病患者的膝下残肢发生鳞状细胞癌。

Squamous cell carcinoma arising in a below-knee stump of a patient with chronic lymphocytic leukemia.

作者信息

Pender Sarah, Lu Alexander K, Hans Sachinder S

机构信息

General Surgery Residency Program, Henry Ford Health, Clinton Township, MI.

Department of Vascular Surgery, Henry Ford Health, Clinton Township, MI.

出版信息

J Vasc Surg Cases Innov Tech. 2024 May 21;10(4):101537. doi: 10.1016/j.jvscit.2024.101537. eCollection 2024 Aug.

DOI:10.1016/j.jvscit.2024.101537
PMID:38989265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11234092/
Abstract

We report a case of localized squamous cell carcinoma arising in the ulceration at the site of a below-knee amputation in a patient with chronic lymphocytic leukemia on treatment with ibrutinib. The patient underwent local excision of the skin and soft tissue with histopathology showing a small focus of well-differentiated squamous cell carcinoma in the specimen. This case highlights the importance of clinical evaluation and histopathological review for underlying malignancy in the setting of amputation stump ulceration.

摘要

我们报告了一例局部鳞状细胞癌病例，该病例发生在一名接受伊布替尼治疗的慢性淋巴细胞白血病患者的膝下截肢部位的溃疡处。患者接受了皮肤和软组织的局部切除，组织病理学检查显示标本中有一小灶高分化鳞状细胞癌。该病例突出了在截肢残端溃疡情况下对潜在恶性肿瘤进行临床评估和组织病理学检查的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad92/11234092/f6f3f1ab588e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad92/11234092/5f9eb9a4a32a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad92/11234092/f6f3f1ab588e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad92/11234092/5f9eb9a4a32a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad92/11234092/f6f3f1ab588e/gr2.jpg

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本文引用的文献

1
Rapid development of squamous cell carcinoma at a split-thickness skin graft donor site.在分层皮片供皮区鳞状细胞癌的快速发展。
Int J Burns Trauma. 2023 Aug 15;13(4):182-184. eCollection 2023.
2
Postamputation diagnosis of squamous cell carcinoma in a patient with lymphedema.一名淋巴水肿患者截肢术后鳞状细胞癌的诊断
J Vasc Surg Cases Innov Tech. 2023 Jan 14;9(1):101100. doi: 10.1016/j.jvscit.2023.101100. eCollection 2023 Mar.
3
Acalabrutinib-related second primary malignancies and nonmelanoma skin cancers in patients with chronic lymphocytic leukaemia (CLL): A systematic review and meta-analysis of randomised controlled trials (RCTs).
慢性淋巴细胞白血病（CLL）患者中与阿卡拉布替尼相关的第二原发性恶性肿瘤和非黑色素瘤皮肤癌：随机对照试验（RCT）的系统评价和荟萃分析。
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Second cancer incidence in CLL patients receiving BTK inhibitors.慢性淋巴细胞白血病患者接受 BTK 抑制剂治疗后的二次癌症发病情况。
Leukemia. 2020 Dec;34(12):3197-3205. doi: 10.1038/s41375-020-0987-6. Epub 2020 Jul 23.
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Marjolin's ulcer: a preventable malignancy arising from scars.马约林溃疡：一种可预防的源于瘢痕的恶性肿瘤。
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Major lower extremity amputations at a Veterans Affairs hospital.一家退伍军人事务医院的主要下肢截肢手术。
Am J Surg. 2003 Nov;186(5):449-54. doi: 10.1016/j.amjsurg.2003.07.027.
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Rates of lower-extremity amputation and arterial reconstruction in the United States, 1979 to 1996.1979年至1996年美国下肢截肢和动脉重建率
Am J Public Health. 1999 Aug;89(8):1222-7. doi: 10.2105/ajph.89.8.1222.