Suppr超能文献

磁响应型生物复合材料在创伤愈合中的应用:从特性到功能。

Magneto-responsive biocomposites in wound healing: from characteristics to functions.

机构信息

Research Institute for Biomaterials, Tech Institute for Advanced Materials, College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211816, China.

出版信息

J Mater Chem B. 2024 Aug 7;12(31):7463-7479. doi: 10.1039/d4tb00743c.

Abstract

The number of patients with non-healing wounds continuously increases, and has become a prominent societal issue that imposes a heavy burden on both patients and the entire healthcare system. Although traditional dressings play an important role in wound healing, the complexity and diversity of the healing process pose serious challenges in this field. Magneto-responsive biocomposites, with their excellent biocompatibility, remote spatiotemporal controllability, and unique convenience, demonstrate enticing advantages in the field of wound dressings. However, current research on magneto-responsive biocomposites as wound dressings lacks comprehensive and in-depth reviews, which to some extent, restricts the deeper understanding and further development of this field. Based on this, this paper reviews the latest advances in magnetic responsive wound dressings for wound healing. First, we review the process of skin wound healing and parameters for assessing repair progress. Then, we systematically discuss the preparation strategies and unique characteristics of magneto-responsive biocomposites, focusing on magneto-induced orientation, magneto-induced mechanical stimulation, and magnetocaloric effect. Subsequently, this review elaborates the multiple mechanisms of magneto-responsive biocomposites in promoting wound healing, including regulating cell behavior, enhancing electrical signal, controlling drug release, and accelerating tissue reconstruction. Finally, we further propose the development direction and future challenges of magnetic responsive biomaterials as wound dressings in clinical application.

摘要

非愈合性伤口的患者数量不断增加,已成为一个突出的社会问题,给患者和整个医疗体系都带来了沉重的负担。尽管传统敷料在伤口愈合中起着重要作用,但愈合过程的复杂性和多样性在这一领域带来了严峻的挑战。磁响应型生物复合材料具有优异的生物相容性、远程时空可控性和独特的便利性,在伤口敷料领域表现出诱人的优势。然而,目前关于磁响应型生物复合材料作为伤口敷料的研究缺乏全面和深入的综述,在某种程度上限制了该领域的深入理解和进一步发展。基于此,本文综述了磁响应型伤口敷料在伤口愈合方面的最新进展。首先,我们回顾了皮肤伤口愈合的过程和评估修复进展的参数。然后,我们系统地讨论了磁响应型生物复合材料的制备策略和独特特性,重点介绍了磁诱导取向、磁诱导机械刺激和磁热效应。随后,本文详细阐述了磁响应型生物复合材料在促进伤口愈合方面的多种机制,包括调节细胞行为、增强电信号、控制药物释放和加速组织重建。最后,我们进一步提出了磁性响应生物材料作为临床应用中伤口敷料的发展方向和未来挑战。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验