Miller M A, Shelley W B
Arch Dermatol. 1985 Sep;121(9):1157-9.
We studied the antibacterial properties of lidocaine and lidocaine with methylparaben, employing bacteria that were isolated from dermal lesions. Our study was significant because local anesthetics utilized before obtaining material for biopsy and/or culture may result in false-negative results. Killing curves were calculated to ascertain exposure times of bacteria to various concentrations of lidocaine with and without methylparaben that could affect recovery of viable bacteria from clinical specimens. The bacteria studied varied greatly in their susceptibility to lidocaine, with Neisseria species being the most sensitive. Greater inhibitory activity was noted against bacteria when methylparaben was present. Our study suggests that lower concentrations of lidocaine without methylparaben should be employed.
我们利用从皮肤损伤处分离出的细菌，研究了利多卡因及含对羟基苯甲酸甲酯的利多卡因的抗菌特性。我们的研究意义重大，因为在获取活检和/或培养材料之前使用局部麻醉剂可能会导致假阴性结果。计算杀菌曲线以确定细菌在有或没有对羟基苯甲酸甲酯的情况下，暴露于不同浓度利多卡因的时间，这可能会影响从临床标本中回收活菌。所研究的细菌对利多卡因的敏感性差异很大，其中奈瑟菌属最为敏感。当存在对羟基苯甲酸甲酯时，对细菌的抑制活性更强。我们的研究表明，应使用较低浓度且不含对羟基苯甲酸甲酯的利多卡因。
