Hymes S R, Farmer E R, Burns W H, Morison W L, Tutschka P J, Walters L L, Santos G W
Arch Dermatol. 1985 Sep;121(9):1189-92.
Cutaneous sclerodermalike changes are a well-documented manifestation of chronic cutaneous graft-vs-host reaction. We describe a patient with chronic cutaneous graft-vs-host reaction who developed vesicles and bullae on sclerodermoid skin 18 months after bone marrow transplantation. The vesicles and bullae were subepidermal in location by light microscopy and were associated with dilated lymphatics and a sparse perivascular mononuclear cell infiltrate. No deposition of immunoreactants was seen by immunofluorescent microscopy. Electron microscopy confirmed the presence of a subepidermal blister beneath an intact basement membrane zone and surrounded by marked dermal edema. We postulate that localized lymphedema may play a role in the development of these vesicles and bullae.
皮肤硬皮病样改变是慢性皮肤移植物抗宿主反应的一种有充分文献记载的表现。我们描述了一名患有慢性皮肤移植物抗宿主反应的患者，该患者在骨髓移植18个月后，在硬皮病样皮肤上出现了水疱和大疱。光镜检查显示水疱和大疱位于表皮下，与扩张的淋巴管和稀疏的血管周围单核细胞浸润有关。免疫荧光显微镜检查未见免疫反应物沉积。电子显微镜证实完整的基底膜带下方存在表皮下水疱，并被明显的真皮水肿包围。我们推测局部淋巴水肿可能在这些水疱和大疱的形成中起作用。
Zotero 插件