Nagler A, Goldenhersh M A, Levi-Schaffer F, Bystryn J C, Klaus S N
Department of Bone Marrow Transplantation, Hebrew University, Jerusalem, Israel.
Br J Dermatol. 1996 Apr;134(4):780-3.
We describe a 14-year-old boy who developed total leucoderma during the course of chronic graft-versus-host disease, which developed after allogeneic bone marrow transplantation. Skin biopsy and dihydroxy-phenylalanine staining revealed a total absence of melanocytes from the epidermis. Cytotoxic anti-melanocyte antibodies were found in the patient's serum, and this probably explains the development of the leucoderma.
我们描述了一名14岁男孩，他在异基因骨髓移植后发生的慢性移植物抗宿主病过程中出现了全身白斑。皮肤活检和二羟基苯丙氨酸染色显示表皮完全没有黑素细胞。在患者血清中发现了细胞毒性抗黑素细胞抗体，这可能解释了白斑的发生。
