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孤独症症状与六个月内适应性功能之间的关联:PARC研究试点阶段的结果

The Association Between Autism Symptomatology and Adaptive Functioning Over Six Months: Findings from the Pilot Phase of the PARC Study.

作者信息

Cohen Tamar David, Koller Judah, Duku Eric, Kata Anna, Anderson Colleen, Bennett Teresa, Cauwenbergs Amber, Dekker Kathleen, DiRezze Briano, Drmic Irene, Eerkes Judy, Gentles Stephen J, Georgiades Kathy, Hoult Lorraine, De Camargo Olaf Kraus, Mahoney Bill, Mesterman Ronit, Ng Olivia, Robertson Sue, Roncadin Caroline, Georgiades Stelios

机构信息

Hebrew University of Jerusalem, Seymour Fox School of Education, Jerusalem, Israel.

Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada.

出版信息

J Autism Dev Disord. 2024 Jul 11. doi: 10.1007/s10803-024-06460-w.

Abstract

PURPOSE

In the context of developmental trajectories, the association between adaptive functioning and core autism symptomatology remains unclear. The current study examines the associations of adaptive behavior with autism symptom sub-domains and with different facets of symptom expression.

METHODS

Participants include 36 children with a recent diagnosis of autism (33 males; mean age = 56.4 months; SD = 9 months). Families were recruited in the context of the Pediatric Autism Research Cohort (PARC) project. Parents filled out questionnaires at two time points, six months apart, regarding their child's autism symptoms and adaptive functioning. The longitudinal relationship between adaptive functioning and autism symptoms was investigated using Mixed Linear Model analyses: one assessing the relationship between general symptom levels and adaptive functioning, and another examining the associations between symptom frequency and impact with adaptive functioning. We conducted Pearson correlation tests at both time points to assess the associations between symptom sub-domains and adaptive functioning.

RESULTS

Findings showed that higher autism symptoms associated with lower adaptive behavior skills, and that this association remained stable over time. Autism impact scores did not significantly relate to adaptive skills, as opposed to frequency scores. Associations between adaptive functioning and autism symptom sub-domains strengthened over time.

CONCLUSION

These findings suggest that adaptive functioning is associated with parent-report autism symptomatology, and that this association changes and, on average, becomes stronger over time. Findings may indicate that frequency and impact of symptoms have differential roles in the development of adaptive skills and are worthy of further exploration.

摘要

目的

在发展轨迹的背景下,适应性功能与孤独症核心症状之间的关联仍不明确。本研究考察适应性行为与孤独症症状子领域以及症状表现不同方面之间的关联。

方法

参与者包括36名近期被诊断为孤独症的儿童(33名男性;平均年龄=56.4个月;标准差=9个月)。这些家庭是在儿童孤独症研究队列(PARC)项目中招募的。家长在两个时间点填写问卷,时间间隔为6个月,内容涉及孩子的孤独症症状和适应性功能。使用混合线性模型分析来研究适应性功能与孤独症症状之间的纵向关系:一个模型评估一般症状水平与适应性功能之间的关系,另一个模型考察症状频率和影响与适应性功能之间的关联。我们在两个时间点都进行了皮尔逊相关检验,以评估症状子领域与适应性功能之间的关联。

结果

研究结果表明,较高的孤独症症状与较低的适应性行为技能相关,且这种关联随时间保持稳定。与频率得分不同,孤独症影响得分与适应性技能没有显著关联。随着时间的推移,适应性功能与孤独症症状子领域之间的关联增强。

结论

这些研究结果表明,适应性功能与家长报告的孤独症症状相关,且这种关联会发生变化,平均而言,随着时间的推移会变得更强。研究结果可能表明,症状的频率和影响在适应性技能发展中具有不同作用,值得进一步探索。

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