Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
PLoS One. 2024 Jul 11;19(7):e0304792. doi: 10.1371/journal.pone.0304792. eCollection 2024.
Despite the rising prevalence of Inflammatory Bowel Disease (IBD), age and sex differences in its outcomes remain understudied. We investigated age and sex differences in IBD patients using a nationwide study in Iran, the Iranian Registry of Crohn's and Colitis (IRCC).
The IRCC is a national registry that gathered information on adult IBD patients since 2017. The collected data included demographic information, medication history, disease activity, comorbidities, diagnosis age, prognosis, the extent of ulcerative colitis (UC), Crohn's disease (CD) location, and extraintestinal manifestations. The statistical methods included the independent Student's t-test, Chi-square test, and binary logistic regression, using R version 4.2.2.
Among the 9,392 IBD patients, 7,496 (3,600 females) and 1,896 (808 females) had UC and CD, respectively. Sex difference showed higher odds of active disease in the past six months in male CD patients (OR 1.24 [95%CI 1.03, 1.49]) vs. females, but in male UC patients, the OR was 0.85 [0.78, 0.93]. Severe disease was less likely in CD patients aged 19-59 and >60 vs. <18. Similarly, UC patients <18 had lower odds of severe disease vs. those aged 19-59 and >60.
This study emphasizes the importance of understanding age and sex differences in IBD outcomes. These findings contribute to the ongoing global discussion on IBD management and facilitate the development of targeted interventions and personalized care.
尽管炎症性肠病（IBD）的患病率不断上升，但该病结局的年龄和性别差异仍研究不足。我们利用伊朗全国性研究——克罗恩病和结肠炎伊朗注册研究（IRCC），调查了 IBD 患者的年龄和性别差异。
IRCC 是自 2017 年以来收集成人 IBD 患者信息的全国性注册研究。收集的数据包括人口统计学信息、药物治疗史、疾病活动度、合并症、诊断年龄、预后、溃疡性结肠炎（UC）的范围、克罗恩病（CD）的部位和肠外表现。统计学方法包括独立样本 t 检验、卡方检验和二项逻辑回归，使用 R 版本 4.2.2。
在 9392 例 IBD 患者中，7496 例（3600 例女性）和 1896 例（808 例女性）分别患有 UC 和 CD。性别差异显示，与女性相比，男性 CD 患者在过去六个月中疾病活动度更高的几率更高（比值比 1.24[95%置信区间 1.03-1.49]），而男性 UC 患者的比值比为 0.85[0.78-0.93]。19-59 岁和>60 岁的 CD 患者与<18 岁的患者相比，严重疾病的可能性较低。同样，与 19-59 岁和>60 岁的患者相比，<18 岁的 UC 患者发生严重疾病的可能性较低。
本研究强调了了解 IBD 结局的年龄和性别差异的重要性。这些发现有助于正在进行的全球 IBD 管理讨论，并促进有针对性的干预措施和个性化护理的发展。
