2018-2019 年,在巴拿马新诊断出 HIV 的人群中评估快速抗逆转录病毒起始策略。
Evaluation of rapid antiretroviral initiation strategy in a cohort of newly diagnosed people living with HIV in Panama, 2018-2019.
机构信息
Juan Pablo Alvis-Estrada, Centro de Estudios en Salud, Universidad del Valle de Guatemala, Guatemala City, Guatemala.
Andrés Azmitia-Rugg, Center for Disease Control and Prevention (CDC) Central America Region, Guatemala City, Guatemala.
出版信息
AIDS Care. 2024 Nov;36(11):1588-1595. doi: 10.1080/09540121.2024.2373397. Epub 2024 Jul 11.
Antiretroviral therapy (ART) has been adopted as a form of HIV treatment and prevention. This study assesses rapid ART initiation using clinical outcomes such as viral load (VL) and CD4+ T lymphocytes count. Over the course of one year, the progress of newly diagnosed people living with HIV who started ART early in a hospital in Panama City was followed. The evaluation of early initiation of ART in achieving viral suppression (VL <200 copies/ml) was analyzed using descriptive statistics. Additionally, the cost difference between early (first 7 days) and late initiation of ART was evaluated from the perspective of the service provider. In total, 209 people were followed up during the study; 85% were male, 70% started ART on same day from hospital arrival, 80% had suppressed viral load at 6 months, and the median count of CD4 increased from 285 (IQR: 166-429) to 509 (IQR: 373-696) over 12 months. Starting ART early led to a 42% increase for the provider in terms of staffing costs; however, the clients had the opportunity to decrease absenteeism in daily activities. The results reveal that early initiation of ART generates clinical and economic benefits for the person in treatment.
抗逆转录病毒疗法 (ART) 已被用作 HIV 治疗和预防的一种形式。本研究通过病毒载量 (VL) 和 CD4+T 淋巴细胞计数等临床结果评估快速开始 ART。在巴拿马城一家医院,对新诊断出的 HIV 感染者在早期开始接受 ART 的情况进行了为期一年的跟踪。使用描述性统计对早期开始 ART 以实现病毒抑制 (VL<200 拷贝/ml) 的效果进行了评估。此外,还从服务提供者的角度评估了早期(前 7 天)和晚期开始 ART 的成本差异。在研究期间共跟踪了 209 人;85%为男性,70%在到达医院当天开始 ART,80%在 6 个月时病毒载量得到抑制,CD4 的中位数计数从 285(IQR:166-429)增加到 12 个月时的 509(IQR:373-696)。早期开始 ART 使提供者的人员成本增加了 42%;然而,患者有机会减少日常活动中的缺勤。结果表明,早期开始 ART 为治疗中的患者带来了临床和经济效益。