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局部用吲哚美辛预处理对氩激光小梁成形术的影响:一项针对南非黑人的随机双盲研究。

Effects of topical indomethacin pretreatment on argon laser trabeculoplasty: a randomised, double-masked study on black South Africans.

作者信息

Gelfand Y A, Wolpert M

出版信息

Br J Ophthalmol. 1985 Sep;69(9):668-72. doi: 10.1136/bjo.69.9.668.

Abstract

This randomised, double-masked study on 45 black South Africans compares the effect of topical indomethacin pretreatment with that of placebo on the immediate postoperative increase or reduction in intraocular pressure one week and one month after argon laser trabeculoplasty. There was no significant difference in the incidence and the magnitude of the immediate postoperative intraocular pressure increase between the two groups, though they occurred significantly later in the indomethacin-treated group (p less than 0.01). Although no effect of indomethacin pretreatment on the intraocular pressure reduction was evident after one week, a significant adverse effect of the drug was demonstrated after one month (p less than 0.01).

摘要

这项针对45名南非黑人的随机双盲研究,比较了局部使用消炎痛预处理与安慰剂对氩激光小梁成形术后1周和1个月时眼内压立即升高或降低的影响。两组术后眼内压立即升高的发生率和幅度没有显著差异,尽管消炎痛治疗组的升高明显出现得更晚(p小于0.01)。虽然消炎痛预处理在1周后对眼压降低没有明显影响,但1个月后该药显示出显著的不良影响(p小于0.01)。

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本文引用的文献

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Trans Ophthalmol Soc U K (1962). 1980 Jul;100(Pt 2):286-90.
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Immediate intraocular pressure response to argon laser trabeculoplasty.
Am J Ophthalmol. 1983 Mar;95(3):279-86. doi: 10.1016/s0002-9394(14)78294-7.
10
Ocular absorption of indomethacin by the rabbit.吲哚美辛在兔眼中的吸收情况。
Arch Ophthalmol. 1972 Aug;88(2):196-8. doi: 10.1001/archopht.1972.01000030198012.

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