阿曲库铵与眼压
Atracurium and intraocular pressure.
作者信息
Murphy D F, Eustace P, Unwin A, Magner J B
出版信息
Br J Ophthalmol. 1985 Sep;69(9):673-5. doi: 10.1136/bjo.69.9.673.
The effect of atracurium on intraocular pressure was studied by comparing it with pancuronium in a randomised controlled trial. The intraocular pressure was measured in patients undergoing cataract surgery before administration of the muscle relaxant, at 1, 3, and 5 minutes after its administration, and at 1 minute after tracheal intubation. Atracurium was found to decrease intraocular pressure to a significantly greater degree than pancuronium. The intraocular pressure after tracheal intubation was found to be significantly higher than that measured immediately after induction of anaesthesia. The authors conclude that atracurium provides an acceptable alternative to pancuronium for ophthalmic surgery but does not overcome the ocular hypertensive effect of tracheal intubation.
在一项随机对照试验中，通过将阿曲库铵与潘库溴铵进行比较，研究了阿曲库铵对眼压的影响。在白内障手术患者中，于给予肌肉松弛剂前、给药后1分钟、3分钟和5分钟以及气管插管后1分钟测量眼压。结果发现，阿曲库铵降低眼压的程度明显大于潘库溴铵。还发现气管插管后的眼压明显高于诱导麻醉后立即测量的眼压。作者得出结论，对于眼科手术，阿曲库铵是潘库溴铵的可接受替代药物，但不能克服气管插管引起的眼内压升高作用。
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