Moreau P L
Biochimie. 1985 Mar-Apr;67(3-4):353-6. doi: 10.1016/s0300-9084(85)80079-1.
The RecA protein of Escherichia coli plays a central role in DNA repair mechanisms. When it is incubated with single-stranded DNA and a nucleoside triphosphate, the purified RecA protein acts both by promoting cleavage of the LexA protein, the repressor of the SOS genes, and by catalyzing strand exchange between a variety of DNA molecules. A model for the regulation of the activity of the RecA protein in a cell exposed to a DNA damaging treatment is proposed.
大肠杆菌的RecA蛋白在DNA修复机制中起着核心作用。当它与单链DNA和核苷三磷酸一起孵育时，纯化的RecA蛋白通过促进SOS基因的阻遏物LexA蛋白的裂解以及催化多种DNA分子之间的链交换来发挥作用。本文提出了一个在受到DNA损伤处理的细胞中调节RecA蛋白活性的模型。
