肺炎链球菌转化中的长片段和短片段基因转换

Long- and short-patch gene conversions in Streptococcus pneumoniae transformation.

作者信息

Sicard M, Lefèvre J C, Mostachfi P, Gasc A M, Méjean V, Claverys J P

出版信息

Biochimie. 1985 Mar-Apr;67(3-4):377-84. doi: 10.1016/s0300-9084(85)80084-5.

DOI:10.1016/s0300-9084(85)80084-5

Abstract

In pneumococcal transformation some point mutations are integrated by an excision-repair pathway which switches the heteroduplex DNA into homoduplex. This transfer of information is a gene conversion. We have reviewed some of the properties of this system especially those relating to heteroduplex specificity and given evidence that this extends over several kilobases of DNA. We then describe a new process of conversion in pneumococcal transformation which occurs over a very short distance (5 to 27 base-pairs) and is triggered by a single site mutation resulting from the transversion 5'-ATTCAT...to 5'...ATTAAT... Only one of the two heteroduplexes 5'...A...3'/3'...G...5', is converted.

摘要

在肺炎球菌转化过程中，一些点突变通过切除修复途径整合，该途径将异源双链DNA转换为同源双链。这种信息传递就是基因转换。我们回顾了该系统的一些特性，特别是与异源双链特异性相关的特性，并给出证据表明这种特异性延伸至数千碱基对的DNA区域。然后我们描述了肺炎球菌转化中一种新的转换过程，该过程发生在非常短的距离（5至27个碱基对）内，由一个由颠换5'-ATTCAT...变为5'...ATTAAT...产生的单点突变引发。两条异源双链5'...A...3'/3'...G...5'中只有一条被转换。

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