氟苯丙胺对12例精神分裂症住院患者阴性症状影响的初步研究。

Pilot study on the effects of fenfluramine on negative symptoms in twelve schizophrenic inpatients.

作者信息

Stahl S M, Uhr S B, Berger P A

出版信息

Biol Psychiatry. 1985 Oct;20(10):1098-102. doi: 10.1016/0006-3223(85)90008-3.

Abstract

We treated 12 chronic schizophrenic inpatients with fenfluramine, an anorexigenic drug that depletes serotonin, to test the hypothesis that the "negative" symptoms of schizophrenia might be related to brain serotonin activity. We measured change in both positive and negative symptoms in a double-blind, parallel-design trial of fenfluramine or placebo. Negative symptoms improved over time in some individuals within the active treatment group, but not in individuals within the placebo group. However, group comparisons of active treatment versus placebo were not significant.

摘要

我们用氟苯丙胺（一种可消耗血清素的食欲抑制药物）治疗了12名慢性精神分裂症住院患者，以检验精神分裂症“阴性”症状可能与大脑血清素活性有关这一假说。在一项关于氟苯丙胺或安慰剂的双盲、平行设计试验中，我们测量了阳性和阴性症状的变化。在积极治疗组中的一些个体中，阴性症状随时间有所改善，但安慰剂组中的个体则没有。然而，积极治疗组与安慰剂组的组间比较并无显著差异。