芬氟拉明在难治性精神分裂症治疗中的不良反应。

Adverse effects of fenfluramine in treatment refractory schizophrenia.

作者信息

Marshall B D, Glynn S M, Midha K K, Hubbard J W, Bowen L L, Banzett L, Mintz J, Liberman R P

机构信息

Department of Psychology, University of California, Los Angeles.

出版信息

J Clin Psychopharmacol. 1989 Apr;9(2):110-5. doi: 10.1097/00004714-198904000-00007.

DOI:10.1097/00004714-198904000-00007

PMID:2656778

Abstract

Fenfluramine was administered to eight severely ill schizophrenic patients as an adjunct to neuroleptic drugs in a double-blind, multiple baseline design. A significant adverse effect of fenfluramine on psychopathology was detected through nurses' ratings, target symptom scales, the Brief Psychiatric Rating Scale, and time-sampled behavioral observations. Clinical deterioration was correlated with fenfluramine-induced reductions in blood serotonin levels and persisted beyond the point of discontinuation of fenfluramine.

摘要

在一项双盲、多基线设计中，对8名重症精神分裂症患者使用芬氟拉明作为抗精神病药物的辅助药物。通过护士评分、目标症状量表、简明精神病评定量表和时间抽样行为观察，发现芬氟拉明对精神病理学有显著不良影响。临床恶化与芬氟拉明引起的血血清素水平降低相关，且在芬氟拉明停药后仍持续存在。