Faculty of Chemical Technology, Hanoi University of Industry, 298 Cau Dien, Bac Tu Liem, Hanoi, Viet Nam.
Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Department of Chemistry, Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
Fitoterapia. 2024 Sep;177:106121. doi: 10.1016/j.fitote.2024.106121. Epub 2024 Jul 9.
Myrsine (the family Primulaceae) contains flowering species. Pharmacologically, the plants of this genus belong to a list of medicinal plants that induce infectious and inflammatory treatments. There are no scientific publications that review phytochemistry and pharmacological activities.
The compilation and classification of phytochemicals, chromatographic information, essential oils, and pharmacological reviews are the ultimate aim.
References on phytochemical and pharmacological investigations of Myrsine species were collected from various sources, such as Google Scholar, PubMed, and Web of Science from the 1990s to present. The main keyword "Myrsine" was used alone or in combination with others to search for references.
Chromatographic procedure of Myrsine extracts led to the purification of 134 compounds. Flavonoids, mono-phenols, saponins, quinones, megastigmanes, and lignans were the main phytochemical classes. Myrsine Volatile compounds are monoterpenoids, sesquiterpenoids, and aliphatic compounds. Myrsine constituents established a widespread panel of pharmacological activities, such as cytotoxicity, antioxidant, antimicrobial, anti-parasite, tyrosine inhibition, and hepatoprotection, especially anti-inflammation. Novel flavonoids myrsininones A-B are better than the standard triclosan against bacteria Staphylococcus warneri, S. mutan, S. sanguis, and Actinomyces naeslundii. M. seguinii aerial part ethanolic extract inhibited LPS (lipopolysaccharide)-stimulated inflammatory Raw 264.7 cells via Src/Syk/NF-κB (sarcoma kinase/spleen tyrosine kinase/ nuclear factor-kappa B) and IRAK-1/AP-1 (interleukin-1 receptor-associated kinase-1/activating protein-1) signaling inhibition. Generally, Myrsine plant extracts showed no toxicity.
Myrsine constituents are good antimicrobial, antioxidative, and anti-inflammatory agents. However, the majority of earlier research focuses on the pharmacological analyses of M. africana. Thus, comprehensive findings for the remaining species are needed.
紫金牛属（报春花科）包含开花物种。药理学上，该属植物属于能治疗感染和炎症的药用植物之列。目前尚无科学文献对其植物化学和药理学活性进行综述。
对紫金牛属植物的植物化学、色谱信息、挥发油和药理学综述进行汇编和分类。
从 20 世纪 90 年代至今，从 Google Scholar、PubMed 和 Web of Science 等多个来源收集有关紫金牛属植物的植物化学和药理学研究的参考文献。主要关键词“紫金牛”单独或组合使用其他关键词进行检索。
紫金牛属植物提取物的色谱程序导致了 134 种化合物的纯化。黄酮类、单酚类、皂苷类、醌类、megastigmanes 和木脂素类是主要的植物化学类群。紫金牛属植物挥发油是单萜类、倍半萜类和脂肪族化合物。紫金牛属植物成分具有广泛的药理活性，如细胞毒性、抗氧化、抗菌、抗寄生虫、酪氨酸抑制和保肝作用，特别是抗炎作用。新型黄酮类化合物 myrsininones A-B 对细菌 Staphylococcus warneri、S. mutan、S. sanguis 和 Actinomyces naeslundii 的抑制作用优于标准三氯生。M. seguinii 地上部分乙醇提取物通过抑制 Src/Syk/NF-κB（肉瘤激酶/脾酪氨酸激酶/核因子-κB）和 IRAK-1/AP-1（白细胞介素-1 受体相关激酶-1/激活蛋白-1）信号通路抑制 LPS（脂多糖）刺激的 Raw 264.7 细胞炎症。一般来说，紫金牛属植物提取物没有毒性。
紫金牛属植物成分是很好的抗菌、抗氧化和抗炎剂。然而，早期研究大多集中在 M. africana 的药理学分析上，因此需要对其余物种进行全面的研究。
