Ophthalmology Clinic, Department of Medicine and Science of Ageing, University "G. D'Annunzio" Chieti- Pescara, via dei Vestini 31, Chieti, 66100, Italy.
Department of Neurosciences, Imaging and Clinical Sciences, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
BMC Ophthalmol. 2024 Jul 11;24(1):279. doi: 10.1186/s12886-024-03538-y.
To report a case of cataract surgery in unintentional Ozurdex (Allergan, Inc., Irvine, California, USA) injection into the lens.
A 82-years old man reporting decreased visual acuity in his right eye came to our Ophthalmology service. Due to the clinical history, and on the basis of ophthalmoscopic and imaging examinations diabetic macular edema was diagnosed. Thus, intravitreal dexamethasone implant was scheduled and therefore performed. The following day Ozurdex appeared to be located into the lens. After careful evaluation and strict follow up examinations, due to the risks associated with the presence of the implant into the lens, phacoemulsification with Ozurdex removal and intraocular lens (IOL) implantation was scheduled and performed.
In this case report we reported the surgical management of accidental into-the lens dexamethasone implant carefully taking into account the dexamethasone pharmacokinetic.
报告一例意外将奥扎格雷（艾尔建公司，加利福尼亚州欧文，美国）注射到晶状体中的白内障手术。
一名 82 岁男性因右眼视力下降前来我院眼科就诊。根据临床病史，并结合眼底镜和影像学检查，诊断为糖尿病性黄斑水肿。因此，计划行玻璃体内注射地塞米松植入物治疗。次日，奥扎格雷似乎位于晶状体中。经过仔细评估和严格随访检查，由于植入物位于晶状体中存在相关风险，因此计划并进行了白内障超声乳化术联合奥扎格雷取出和人工晶状体（IOL）植入术。
在本病例报告中，我们报道了意外将地塞米松植入晶状体后的手术处理方法，同时仔细考虑了地塞米松的药代动力学。
