Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Center for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Environ Pollut. 2024 Oct 15;359:124474. doi: 10.1016/j.envpol.2024.124474. Epub 2024 Jul 9.
In April 2023, the World Health Organization (WHO) reported that 17.5% of the global adult population experience infertility. What may be the contribution of per-and polyfluoroalkyl (PFAS) to this global public health problem? This study explored the associations between in vitro fertilization (IVF) outcomes and plasma concentrations of individual PFAS and PFAS mixtures in women undergoing in vitro fertilization and embryo transfer (IVF-ET) and how these exposures might affect IVF outcomes. We analyzed 8 PFASs in plasma samples from women (N = 259) who underwent IVF treatment. In multivariable generalized linear mixed models, there were statistically significant associations of higher plasma concentrations of PFNA with reduced numbers of total retrieved oocytes [12.486 (95%CI: 0.446,25.418), p trend = 0.017], 2 PN zygotes [6.467(95%CI: 2.034,14.968), p trend = 0.007], and cleavage embryos [6.039(95%CI: 2.162,14.240), p trend = 0.008]. Similarly, there was a continuous decline in the numbers of retrieved 2 PN zygotes and cleavage embryos with increasing concentration of PFOS [6.467(95%CI: 2.034,14.968), p trend = 0.009 and 6.039(95%CI: 2.162,14.240), p trend = 0.031,respectively] and a negative association between PFHxS concentrations and clinical pregnancy during the initial cycles of frozen ET [0.525(95%CI:0.410,0.640), p trend = 0.021]. To investigate the joint effect of PFAS mixtures, a confounder-adjusted BKMR model analysis showed inverse relationship between PFAS mixtures and the number of high-quality embryos, 2 PN zygotes and cleavage embryos, to which the greatest contributors to the mixture effect are PFDeA and PFBS, respectively. It demonstrated that PFAS exposure might exert negative effects on oocyte yield, fertilization and high-quality embryo in women undergoing IVF. These findings suggest that exposure to PFAS may increase the risk of female infertility and further studies are needed to uncover the potential mechanisms underlying the reproductive effects associated with PFAS.
2023 年 4 月，世界卫生组织（WHO）报告称，全球有 17.5%的成年人口患有不孕症。全氟和多氟烷基物质（PFAS）在这一全球公共卫生问题中可能起到了什么作用？本研究探讨了接受体外受精和胚胎移植（IVF-ET）的女性的血浆中个别 PFAS 和 PFAS 混合物与体外受精结果之间的关联，以及这些暴露如何影响 IVF 结果。我们分析了 259 名接受 IVF 治疗的女性的血浆样本中的 8 种 PFAS。在多变量广义线性混合模型中，PFNA 血浆浓度较高与总获卵数减少呈统计学显著相关[12.486（95%CI：0.446，25.418），p 趋势=0.017]、2 个原核胚胎[6.467（95%CI：2.034，14.968），p 趋势=0.007]和分裂胚胎[6.039（95%CI：2.162，14.240），p 趋势=0.008]。同样，随着 PFOS 浓度的增加，获 2 个原核胚胎和分裂胚胎的数量呈连续下降趋势[6.467（95%CI：2.034，14.968），p 趋势=0.009 和 6.039（95%CI：2.162，14.240），p 趋势=0.031]，而 PFHxS 浓度与冷冻 ET 初始周期的临床妊娠呈负相关[0.525（95%CI：0.410，0.640），p 趋势=0.021]。为了研究 PFAS 混合物的联合效应，经过混杂因素调整的 BKMR 模型分析表明，PFAS 混合物与高质量胚胎、2 个原核胚胎和分裂胚胎的数量之间呈负相关，其中对混合物效应贡献最大的分别是 PFDeA 和 PFBS。这表明 PFAS 暴露可能对接受 IVF 的女性的卵子产量、受精和高质量胚胎产生负面影响。这些发现表明，接触 PFAS 可能会增加女性不孕的风险，需要进一步研究以揭示与 PFAS 相关的生殖效应的潜在机制。
