Sharma Deepika, Chatterjee Rana, Dhayalan Vasudevan, Dandela Rambabu
Department of Industrial and Engineering Chemistry, Institute of Chemical Technology, Indian Oil Odisha Campus, IIT Kharagpur Extension Centre, Mouza Samantapuri, Bhubaneswar-751013, Odisha, India.
Department of Chemistry, National Institute of Technology Puducherry, Karaikal-609609, Puducherry, India.
Org Biomol Chem. 2024 Jul 24;22(29):5913-5917. doi: 10.1039/d4ob00830h.
A simple and efficient oxidative coupling of aromatic alkynes with elemental sulphur and secondary amines has been reported. The iodine/DMSO system easily promoted the transformations, affording thioglyoxamides C-S, C-O, and C-N bond formations. In this context, acetylenic C-H bond oxidation has occurred through iodination, leading to the desired products. Moreover, this metal-free, one-pot protocol is accomplished by using readily available starting materials, without external oxidants, and under aerobic conditions, providing a variety of α-ketothioamide compounds in moderate to good yields.
