Department of Industrial and Engineering Chemistry, Institute of Chemical Technology, Indian Oil Odisha Campus, Samantpuri, Bhubaneswar 751013, India.
Org Biomol Chem. 2022 May 18;20(19):3907-3912. doi: 10.1039/d2ob00458e.
A convenient and practical synthetic approach for α-ketoamides has been developed under mild conditions. The facile synthesis of α-ketoamides has been accomplished using aryl vinyl azides and secondary amines at room temperature. The inexpensive and readily available iodine and TBHP easily promoted the oxidative amidation process to afford diketoamide derivatives in high yields. This method involves the synthesis of ketoamide compounds sequential C-O and C-N bond formation. Moreover, metal-free and aerobic conditions and wide substrate scope are the notable advantages of this protocol.
现已开发出一种在温和条件下方便实用的α-酮酰胺合成方法。在室温下，芳基乙烯基叠氮化物和仲胺可轻松合成α-酮酰胺。廉价且易得的碘和 TBHP 可轻松促进氧化酰胺化过程，以高产率得到二酮酰胺衍生物。该方法涉及酮酰胺化合物的合成，包括顺序的 C-O 和 C-N 键形成。此外，该方法还具有无金属和需氧条件以及宽底物范围的显著优点。
