半乳糖胺修饰的 CaCO3 纳米免疫调节剂用于针对原位肝癌的靶向和响应性免疫治疗。
A GalNAc-modified CaCO nano-immunomodulator for targeted and responsive immunotherapy against orthotopic liver cancer.
机构信息
College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, P. R. China.
Laoshan Laboratory, Qingdao, 266237, P. R. China.
出版信息
Chem Commun (Camb). 2024 Jul 30;60(62):8103-8106. doi: 10.1039/d4cc01207k.
A nano-immunomodulator modified with -acetylgalactosamine (GalNAc) on calcium carbonate (CaCO) was prepared for targeted and responsive immunotherapy. And the immunologic adjuvant (CpG ODNs) and doxorubicin (DOX) were released to synergistically improve immune response for treating orthotopic liver cancer.
一种经半乳糖胺（GalNAc）修饰的碳酸钙（CaCO）纳米免疫调节剂被制备用于靶向和响应性免疫治疗。同时，免疫佐剂（CpG ODNs）和阿霉素（DOX）被释放以协同提高免疫反应，用于治疗原位肝癌。
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