Oakley B R
Can J Biochem Cell Biol. 1985 Jun;63(6):479-88. doi: 10.1139/o85-067.
Genetics has become an important tool for studying microtubule structure and function. Mutations in genes that encode microtubule proteins have been isolated in several, evolutionarily diverse organisms. These mutations have been, and will increasingly be, of great value in determining which cellular events are microtubule mediated, in determining which genes encode the microtubule proteins involved in a particular cellular event, and in determining the mechanisms of resistance to anti-microtubule drugs. These mutants also have great potential, which is just beginning to be realized, for identifying proteins other than alpha- and beta-tubulin that are essential to microtubule function and for determining the mechanisms of microtubule-based force production in mitosis and organellar movement.
遗传学已成为研究微管结构和功能的重要工具。在几种进化上不同的生物体中，已分离出编码微管蛋白的基因突变。这些突变在确定哪些细胞事件是由微管介导的、确定哪些基因编码参与特定细胞事件的微管蛋白以及确定对抗微管药物的耐药机制方面，一直并将越来越具有重要价值。这些突变体在识别除α和β微管蛋白之外对微管功能至关重要的蛋白质，以及确定有丝分裂和细胞器运动中基于微管的力产生机制方面，也具有巨大潜力，而这种潜力才刚刚开始被认识到。
