Yang Yiyue, Gu Kaiqi, Li Jing
Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Front Psychiatry. 2024 Jun 27;15:1422511. doi: 10.3389/fpsyt.2024.1422511. eCollection 2024.
Studies have shown that increased inflammatory cytokines are associated with suicide risk, but the relationship between suicide risk and inflammatory cytokines is not clear. This study aimed to investigate the relationship between specific inflammatory markers and suicide risk in patients with MDD.
This is a cross-sectional study. Firstly, we measured and compared psychological characteristics and 10 peripheral inflammatory cytokines in 130 MDD patients and 130 healthy controls(HC). Secondly, MDD patients were divided into 4 groups according to the severity of suicide risk for comparison between groups. Finally, multiple linear regression analysis was used to explore the predictors of suicide risk.
We found that the group with higher suicide risk had higher levels of IL-6, CRP, TNF-α, CXCL-2, and IFN-γ, and lower levels of IL-2 and IL-8 (all p<0.01). However, we found no difference in CRP between MIS and LS groups (p=0.337). Regression models were well-fitted. IL-2,IL-8 negatively predicted suicide risk (all p<0.05),IL-6,CRP,TNF-α,CXCL-2, and IFN-γ can positively predict the risk of suicide (all p<0.05).
This study employed a self-assessment scale.
The higher the levels of IL-6, CRP, TNF-α, CXCL-2, and IFN-γ and the lower the levels of IL-2 and IL-8 of MDD patients, the higher the risk of suicide.
研究表明，炎症细胞因子增加与自杀风险相关，但自杀风险与炎症细胞因子之间的关系尚不清楚。本研究旨在探讨重度抑郁症（MDD）患者特定炎症标志物与自杀风险之间的关系。
这是一项横断面研究。首先，我们测量并比较了130例MDD患者和130例健康对照者（HC）的心理特征和10种外周炎症细胞因子。其次，根据自杀风险的严重程度将MDD患者分为4组进行组间比较。最后，采用多元线性回归分析探讨自杀风险的预测因素。
我们发现自杀风险较高的组中白细胞介素-6（IL-6）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、CXC趋化因子配体2（CXCL-2）和干扰素-γ（IFN-γ）水平较高，而白细胞介素-2（IL-2）和白细胞介素-8（IL-8）水平较低（均p<0.01）。然而，我们发现中度自杀意念（MIS）组和低度自杀意念（LS）组之间的CRP没有差异（p=0.337）。回归模型拟合良好。IL-2、IL-8对自杀风险有负向预测作用（均p<0.05），IL-6、CRP、TNF-α、CXCL-2和IFN-γ对自杀风险有正向预测作用（均p<0.05）。
本研究采用了自评量表。
MDD患者IL-6、CRP、TNF-α、CXCL-2和IFN-γ水平越高，IL-2和IL-8水平越低，自杀风险越高。
