Xu Tianmei, Mao Yanping, Wang Ye, Zhang Wenxuan, Cao Haojun, Yu Enyan
The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Department of Psychiatry, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, China.
Front Psychiatry. 2025 Jul 30;16:1610730. doi: 10.3389/fpsyt.2025.1610730. eCollection 2025.
With the aging global population, the prevalence of late-life depression (LLD) has shown a significant upward trend. The prolonged presence of a depressed mood can lead to feelings of hopelessness and helplessness, thereby enhancing suicidal impulses and behaviors, which seriously affect the physical and mental health of the older population. However, current research on suicide has mainly focused on adolescents and adults, resulting in a lack of data on the identification, assessment, and intervention of suicide risk in LLD. LLD treatments include psychotherapy, medication, physiotherapy, and Internet intervention techniques. First-line antidepressants, in addition to cognitive behavioral therapy and repetitive transcranial magnetic stimulation, have been shown to be effective in patients with LLD. In this study, we review the research progress in the following three aspects: symptomatological characteristics, assessment tools, and treatment methods of suicide in LLD, providing a reference for clinical workers and researchers in clinical practice.
随着全球人口老龄化,老年期抑郁症(LLD)的患病率呈显著上升趋势。长期情绪低落会导致绝望和无助感,从而增强自杀冲动和行为,严重影响老年人群的身心健康。然而,目前关于自杀的研究主要集中在青少年和成年人,导致缺乏关于LLD自杀风险识别、评估和干预的数据。LLD的治疗方法包括心理治疗、药物治疗、物理治疗和互联网干预技术。除认知行为疗法和重复经颅磁刺激外,一线抗抑郁药已被证明对LLD患者有效。在本研究中,我们从以下三个方面综述LLD自杀的研究进展:症状学特征、评估工具和治疗方法,为临床工作者和研究人员的临床实践提供参考。
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