Tan Huey Jing R, Ling Shiao Ling, Khairuddin Norashikin, Lim Wan Yi, Sanggar Arunah, Chemi Norliza Bt
Department of Psychiatry and Mental Health, Hospital Kajang, Ministry of Health Malaysia, Kajang, MYS.
Department of Psychiatry, Amarantine Clinic, Kuala Lumpur, MYS.
Cureus. 2024 Jun 10;16(6):e62106. doi: 10.7759/cureus.62106. eCollection 2024 Jun.
Non-compliance to medications remains a challenging problem in schizophrenia. Newer strategies with high feasibility and acceptability are always being researched. This study aimed to assess the effectiveness of technology-based intervention in improving medication compliance in individuals with schizophrenia.
This was a prospective intervention study where participants were required to use the SuperMD smartphone application (Digital-Health Technologies Pte Ltd, Kuala Lumpur, Malaysia) for a month. A change in the Medication Adherence Rating Scale-Malay Translation (MARS-M) and Malay Translation of Drug Adherence Inventory-9 (MDAI-9) scores indicated a change in compliance and attitude to medication. Positive and Negative Syndrome Scale (PANSS) was used to assess change in symptoms and insight. Medication compliance was also obtained from the SuperMD applicationPaired T-test was used to evaluate the significance of changes in mean scores of research variables over the study period. Wilcoxon signed-rank test was used to analyze the subscale of MDAI-9 and the change in PANSS score. The Kruskal-Wallis test was used to determine the effect of the change of insight on the level of compliance with medication.
There were 36 participants in this study. The results showed statistically significant improvement in compliance (0.65, p ≤ 0.01) but not in attitude towards medication (0.78, p = 0.065). There was also an improvement in PANNS score (-2.58, P ≤ 0.01). There was no significant change in insight (χ(2) = 3.802, p = 0.15) Conclusion:The use of technology-based strategies like SuperMD is effective in improving medication compliance for individuals with schizophrenia.
在精神分裂症患者中，不遵医嘱服药仍然是一个具有挑战性的问题。人们一直在研究具有高可行性和可接受性的新策略。本研究旨在评估基于技术的干预措施对提高精神分裂症患者药物依从性的有效性。
这是一项前瞻性干预研究，要求参与者使用SuperMD智能手机应用程序（马来西亚吉隆坡数字健康技术私人有限公司）一个月。药物依从性评分量表-马来语翻译版（MARS-M）和药物依从性量表-9马来语翻译版（MDAI-9）得分的变化表明依从性和对药物态度的变化。采用阳性和阴性症状量表（PANSS）评估症状和自知力的变化。药物依从性也可从SuperMD应用程序中获取。配对t检验用于评估研究变量平均得分在研究期间变化的显著性。Wilcoxon符号秩检验用于分析MDAI-9的子量表和PANSS得分的变化。Kruskal-Wallis检验用于确定自知力变化对药物依从性水平的影响。
本研究共有36名参与者。结果显示，依从性有统计学意义的改善（0.65，p≤0.01），但对药物的态度没有改善（0.78，p = 0.065）。PANNS评分也有所改善（-2.58，P≤0.01）。自知力无显著变化（χ(2)=3.802，p = 0.15）。结论：使用SuperMD等基于技术的策略可有效提高精神分裂症患者的药物依从性。
