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因笑而跌倒：一氧化二氮所致的亚急性联合变性

Falling From Laughing: Laughing Gas-Induced Subacute Combined Degeneration From Nitrous Oxide.

作者信息

Rao Abhinav K, Syed Fahim, Lee Thomas J, Umanzor Gilberto U, Bodle Jeffrey

机构信息

Internal Medicine, Trident Medical Center, Charleston, USA.

Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA.

出版信息

Cureus. 2024 Jun 11;16(6):e62138. doi: 10.7759/cureus.62138. eCollection 2024 Jun.

DOI:10.7759/cureus.62138
PMID:38993425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11238261/
Abstract

Laughing gas is becoming increasingly popular as a recreational drug of choice, particularly among young adults. Nitrous oxide, the toxic component of laughing gas, can cause neuronal injury when used in high doses. Through multiple mechanisms, nitrous oxide leads to B12 depletion and subsequent demyelination, particularly in the spinal cord. Here, we present the case of a 27-year-old female who presented with ataxia and was found to have laughing gas-induced subacute combined degeneration from nitrous oxide. After aggressive vitamin B12 repletion and laughing gas cessation for three months, the patient improved.

摘要

笑气作为一种消遣性毒品正越来越受欢迎，尤其是在年轻人中。笑气中的有毒成分一氧化二氮在高剂量使用时会导致神经元损伤。一氧化二氮通过多种机制导致维生素B12缺乏及随后的脱髓鞘，尤其是在脊髓。在此，我们报告一例27岁女性患者，她出现共济失调，被发现患有笑气引起的亚急性联合变性。在积极补充维生素B12并停用笑气三个月后，患者病情有所改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1f0/11238261/a103683bca80/cureus-0016-00000062138-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1f0/11238261/dd534d6f1807/cureus-0016-00000062138-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1f0/11238261/a103683bca80/cureus-0016-00000062138-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1f0/11238261/dd534d6f1807/cureus-0016-00000062138-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1f0/11238261/a103683bca80/cureus-0016-00000062138-i02.jpg

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Blood Homocysteine Levels Mediate the Association Between Blood Lead Levels and Cardiovascular Mortality.血液同型半胱氨酸水平介导血铅水平与心血管死亡率之间的关联。
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