Chetana Naga Sai Tarani, Narayanan Ramakrishna, Uppin Megha S, Kanala Ramanadha Reddy
Radiology, Nizam's Institute of Medical Sciences, Hyderabad, IND.
Pathology, Nizam's Institute of Medical Sciences, Hyderabad, IND.
Cureus. 2024 Jun 11;16(6):e62167. doi: 10.7759/cureus.62167. eCollection 2024 Jun.
Primary intracranial germ cell tumors are rare tumors that often occur in children and young adults. We report a case of a 17-year-old male, who presented with vomiting, headache, and blurring of vision of the left eye on the temporal aspect for two months. His biological assessment showed panhypopituitarism. Serum markers showed elevated beta human chorionic gonadotropin and lactate dehydrogenase. A solid cystic lesion was noted on imaging, involving the sella, parasellar region, and pineal region with calcifications within. Diagnosis of bifocal germinoma was confirmed by tumor biopsy. The treatment protocol for the patient involved four cycles of chemotherapy using etoposide and carboplatin, followed by a course of radiotherapy.
原发性颅内生殖细胞肿瘤是罕见肿瘤,常发生于儿童和青年。我们报告一例17岁男性患者,其出现呕吐、头痛及左眼颞侧视力模糊症状达两个月。他的生物学评估显示全垂体功能减退。血清标志物显示β-人绒毛膜促性腺激素和乳酸脱氢酶升高。影像学检查发现一个实性囊性病变,累及鞍区、鞍旁区域及松果体区,内部有钙化。肿瘤活检确诊为双灶性生殖细胞瘤。该患者的治疗方案包括使用依托泊苷和顺铂进行四个周期的化疗,随后进行一个疗程的放疗。