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中国的酒精性肝病:一种受复杂社会因素影响且不容忽视的疾病。

Alcoholic Liver Disease in China: A Disease Influenced by Complex Social Factors That Should Not Be Neglected.

作者信息

Feng Xiaofeng, Huang Nafei, Wu Yuqin, Gao Fei, Chen Xiaomei, Zhang Chenyi, Zhang Bing, Sun Tao

机构信息

The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

出版信息

J Clin Transl Hepatol. 2024 Jul 28;12(7):677-684. doi: 10.14218/JCTH.2024.00034. Epub 2024 May 31.

Abstract

Alcoholic liver disease (ALD) encompasses liver damage caused by chronic, excessive alcohol consumption. It manifests initially as marked hepatocellular steatosis and can progress to steatohepatitis, liver fibrosis, and cirrhosis. With China's rapid economic growth, coupled with a complex social background and the influence of a deleterious wine culture, the number of patients with ALD in China has increased significantly; the disease has become a social and health problem that cannot be ignored. In this review, we briefly described the social factors affecting ALD in China and elaborated on differences between alcoholic and other liver diseases in terms of complications (e.g., cirrhosis, upper gastrointestinal bleeding, hepatic encephalopathy, hepatocellular carcinoma, addiction, and other extrahepatic diseases). We also emphasized that ALD was more dangerous and difficult to treat than other liver diseases due to its complications, and that precise and effective treatment measures were lacking. In addition, we considered new ideas and treatment methods that may be generated in the future.

摘要

酒精性肝病(ALD)包括因长期过量饮酒导致的肝脏损伤。其最初表现为明显的肝细胞脂肪变性,并可进展为脂肪性肝炎、肝纤维化和肝硬化。随着中国经济的快速增长,加上复杂的社会背景和有害酒文化的影响,中国ALD患者数量显著增加;该疾病已成为一个不可忽视的社会和健康问题。在本综述中,我们简要描述了影响中国ALD的社会因素,并阐述了酒精性肝病与其他肝病在并发症(如肝硬化、上消化道出血、肝性脑病、肝细胞癌、成瘾及其他肝外疾病)方面的差异。我们还强调,由于其并发症,ALD比其他肝病更危险且更难治疗,并且缺乏精确有效的治疗措施。此外,我们还探讨了未来可能产生的新思路和治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/528c/11233974/01927e2f3c1a/JCTH-12-677-g001.jpg

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