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Neuropsychiatry of Histaminergic Circuits: Potential Role of Novel H3 Receptor Selective Antagonist/Inverse Agonist Pitolisant in Prader-Willi Syndrome.

作者信息

Freitas Beatriz, Teodoro Tomas P

机构信息

Freitas, MMed, Acute Inpatient Ward, Department of Psychiatry and Mental Health, Centro Hospitalar Psiquiátrico de Lisboa, Lisbon, Portugal; Sintra Community Mental Health Team (CINTRA-Centro Integrado de Tratamento e Reabilitação em Ambulatório em Sintra), Department of Psychiatry and Mental Health, Centro Hospitalar Psiquiátrico de Lisboa, Lisbon, Portugal; Dual Disorders Clinic, Alcohol Misuse and New Addictions Unit, Department of Psychiatry and Mental Health, Centro Hospitalar Psiquiátrico de Lisboa, Lisbon, Portugal.

Teodoro, MD, MBBS, MD, MSc, MMed, Neuropsychiatry Neurorehabilitation Unit & Virtual FND Digital Neurorehabilitation Service, The Wolfson Neurorehabilitation Centre, Queen Mary's Hospital, Department of Neurosciences, St George's University Hospitals NHS Foundation Trust, London, United Kingdom; Comprehensive Health Research Centre, NOVA Medical School, NOVA University Lisbon, Lisbon, Portugal.

出版信息

Psychopharmacol Bull. 2024 Jul 8;54(3):103-107.

PMID:38993657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11235577/
Abstract
摘要

相似文献

1
Neuropsychiatry of Histaminergic Circuits: Potential Role of Novel H3 Receptor Selective Antagonist/Inverse Agonist Pitolisant in Prader-Willi Syndrome.组胺能神经回路的神经精神病学：新型H3受体选择性拮抗剂/反向激动剂匹莫林在普拉德-威利综合征中的潜在作用。
Psychopharmacol Bull. 2024 Jul 8;54(3):103-107.
2
Pitolisant for treating patients with narcolepsy.用于治疗嗜睡症患者的培哚沙胺。
Expert Rev Clin Pharmacol. 2020 Feb;13(2):79-84. doi: 10.1080/17512433.2020.1714435. Epub 2020 Jan 23.
3
Epigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H receptor for Prader-Willi Syndrome.表观遗传学与 G 蛋白偶联受体相遇：组蛋白 H3 甲基转移酶 (G9a) 和组氨酸 H 受体抑制剂治疗普拉德-威利综合征。
Sci Rep. 2020 Aug 11;10(1):13558. doi: 10.1038/s41598-020-70523-y.
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Histamine H receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice.组胺 H 受体反向激动剂/拮抗剂影响静息状态下皮质内区域活动和皮质间同步：在小鼠中的皮层全脑成像研究的探索性研究。
Mol Brain. 2024 Nov 27;17(1):88. doi: 10.1186/s13041-024-01165-8.
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Progress in the development of histamine H receptor antagonists/inverse agonists: a patent review (2013-2017).组胺H受体拮抗剂/反向激动剂的研发进展：专利综述（2013 - 2017年）
Expert Opin Ther Pat. 2018 Mar;28(3):175-196. doi: 10.1080/13543776.2018.1424135. Epub 2018 Jan 15.
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Histamine H3 receptor antagonism modulates autism-like hyperactivity but not repetitive behaviors in BTBR T+Itpr3tf/J inbred mice.组胺H3受体拮抗作用可调节BTBR T+Itpr3tf/J近交系小鼠的自闭症样多动，但对重复行为无影响。
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Antihistamine agents and pitolisant might be useful for anorexia nervosa.抗组胺药和托吡酯可能对神经性厌食症有用。
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Histamine H receptor antagonists/inverse agonists: Where do they go?组胺 H 受体拮抗剂/反向激动剂：它们的去向如何？
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Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors.新型组胺H3受体反向激动剂S 38093的作用机制表征
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本文引用的文献

1
Safety of pitolisant: a study in the WHO international pharmacovigilance database.匹托品的安全性：世界卫生组织国际药物警戒数据库中的一项研究。
Eur J Clin Pharmacol. 2023 Apr;79(4):569-570. doi: 10.1007/s00228-023-03460-0. Epub 2023 Mar 9.
2
Sleep Disorders in Adults with Prader-Willi Syndrome: Review of the Literature and Clinical Recommendations Based on the Experience of the French Reference Centre.普拉德-威利综合征成人患者的睡眠障碍：基于法国参考中心经验的文献综述与临床建议
J Clin Med. 2022 Apr 2;11(7):1986. doi: 10.3390/jcm11071986.
3
Approach to the Patient With Prader-Willi Syndrome.普拉德-威利综合征患者的处理方法。
J Clin Endocrinol Metab. 2022 May 17;107(6):1698-1705. doi: 10.1210/clinem/dgac082.
4
Neuropsychiatric features of Prader-Willi syndrome.普拉德-威利综合征的神经精神特征。
Am J Med Genet A. 2022 May;188(5):1457-1463. doi: 10.1002/ajmg.a.62662. Epub 2022 Jan 30.
5
Histamine H3 receptor antagonism modulates autism-like hyperactivity but not repetitive behaviors in BTBR T+Itpr3tf/J inbred mice.组胺H3受体拮抗作用可调节BTBR T+Itpr3tf/J近交系小鼠的自闭症样多动，但对重复行为无影响。
Pharmacol Biochem Behav. 2022 Jan;212:173304. doi: 10.1016/j.pbb.2021.173304. Epub 2021 Nov 29.
6
Changes in Histaminergic System in Neuropsychiatric Disorders and the Potential Treatment Consequences.神经精神疾病中组胺能系统的变化及潜在的治疗后果。
Curr Neuropharmacol. 2022;20(2):403-411. doi: 10.2174/1570159X19666210909144930.
7
Histamine receptors, agonists, and antagonists in health and disease.组胺受体、激动剂和拮抗剂在健康和疾病中的作用。
Handb Clin Neurol. 2021;180:377-387. doi: 10.1016/B978-0-12-820107-7.00023-9.
8
Pitolisant and Other Histamine-3 Receptor Antagonists-An Update on Therapeutic Potentials and Clinical Prospects.匹托利生及其他组胺-3受体拮抗剂——治疗潜力与临床前景的最新进展
Medicines (Basel). 2020 Sep 1;7(9):55. doi: 10.3390/medicines7090055.
9
Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model.匹哚沙明可保护长期接受皮质酮治疗的小鼠免受皮质酮诱导的抑郁模型中一些行为而非代谢变化的影响。
Pharmacol Biochem Behav. 2020 Sep;196:172974. doi: 10.1016/j.pbb.2020.172974. Epub 2020 Jun 19.
10
Systematic Review and Meta-analysis: Mental Health in Children With Neurogenetic Disorders Associated With Intellectual Disability.系统评价和荟萃分析：智力残疾相关神经遗传疾病患儿的心理健康。
J Am Acad Child Adolesc Psychiatry. 2020 Sep;59(9):1036-1048. doi: 10.1016/j.jaac.2020.01.006. Epub 2020 Jan 13.