Jensen K, Tfelt-Hansen P, Lauritzen M, Olesen J
Cephalalgia. 1985 Sep;5(3):125-31. doi: 10.1046/j.1468-2982.1985.0503125.x.
In a randomized, double-blind cross-over study, 43 patients with classic migraine received 40 mg Nimodipine and placebo as sublingual capsules. There was no significant effect on patients' preference, development of headache, need for escape medicine, duration of headache, severity of headache or headache index. Considerable methodological problems were encountered. Only 54% of the 79 patients selected for the trial could be evaluated. Suggestions for future trials are made.
在一项随机、双盲交叉研究中，43例典型偏头痛患者接受了40毫克尼莫地平及作为舌下胶囊的安慰剂。这对患者的偏好、头痛的发生、急救药物的需求、头痛持续时间、头痛严重程度或头痛指数均无显著影响。研究遇到了相当多的方法学问题。入选该试验的79例患者中只有54%可进行评估。文中还给出了对未来试验的建议。
