Miyamori I, FitzGerald G A, Brown M J, Lewis P J
J Clin Endocrinol Metab. 1979 Dec;49(6):943-4. doi: 10.1210/jcem-49-6-943.
The effect of prostacyclin (PGI2) on the renin-angiotensin-aldosterone system (RAA) has been examined in 6 normal male volunteers infused with 3 incremental doses of PGI2. Diastolic blood pressure fell significantly during the infusion of the highest dose of 8 ng/kg/min. Plasma renin activity (PRA) and plasma angiotensin II (AII) increased to 271% and 342% respectively from baseline values. Plasma cortisol (PC), plasma noradrenaline (PNA) and plasma adrenaline (PAD) did not change significantly. Plasma aldosterone (PA) increased slightly 15 minutes after stopping the infusion. These results suggest aht PGI2 stimulates the release of renin in man.
在6名正常男性志愿者中，通过静脉输注3个递增剂量的前列环素（PGI2），研究了PGI2对肾素-血管紧张素-醛固酮系统（RAA）的影响。在输注最高剂量8 ng/kg/min期间，舒张压显著下降。血浆肾素活性（PRA）和血浆血管紧张素II（AII）分别较基线值升高至271%和342%。血浆皮质醇（PC）、血浆去甲肾上腺素（PNA）和血浆肾上腺素（PAD）无显著变化。停止输注后15分钟，血浆醛固酮（PA）略有升高。这些结果表明，PGI2可刺激人体肾素释放。
