一名慢性肝衰竭患者的肝淀粉样变性：病例报告。
Hepatic amyloidosis in a patient with chronic liver failure: A case report.
作者信息
Chen Yan, Peng Jing, Wang Yao, Xiao Li-Hua, Liu Fang, Wei Yin-Bin, Wu Xiong-Fei, Wang Lu-Wen
机构信息
Department of Infectious Diseases, Hanchuan People's Hospital, Hanchuan 431699, Hubei Province, China.
Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.
出版信息
World J Clin Cases. 2024 Jul 6;12(19):3918-3924. doi: 10.12998/wjcc.v12.i19.3918.
BACKGROUND
Amyloidosis is a rare disorder that can be classified into various types, and the most common type is the systemic light chain type. The prognosis of this disease is extremely poor. In general, amyloidosis mainly affects the kidneys and heart and manifests as abnormal proliferation of clonal plasma cells. Cases in which the liver is the primary organ affected by amyloidosis, as in this report, are less common in clinical practice.
CASE SUMMARY
A 62-year-old man was admitted with persistent liver dysfunction of unknown cause and poor treatment outcomes. His condition persisted, and he developed chronic liver failure, with severe cholestasis in the later stage that was gradually accompanied by renal injury. Ultimately, he was diagnosed with hepatic amyloidosis through liver biopsy and pathological examination.
CONCLUSION
Hepatic amyloidosis rarely occurs in the clinic, and liver biopsy and pathological examination can assist in the accurate and effective diagnosis of this condition.
背景
淀粉样变性是一种罕见疾病，可分为多种类型，最常见的类型是系统性轻链型。这种疾病的预后极差。一般来说，淀粉样变性主要影响肾脏和心脏，表现为克隆性浆细胞异常增殖。像本报告中肝脏是受淀粉样变性影响的主要器官的病例，在临床实践中较少见。
病例摘要
一名62岁男性因不明原因的持续性肝功能障碍及治疗效果不佳入院。其病情持续存在，发展为慢性肝衰竭，后期出现严重胆汁淤积，并逐渐伴有肾损伤。最终，通过肝脏活检和病理检查确诊为肝淀粉样变性。
结论
肝淀粉样变性在临床上很少见，肝脏活检和病理检查有助于准确、有效地诊断该病。
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