College of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Naniing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China.
Front Immunol. 2024 Jun 27;15:1440309. doi: 10.3389/fimmu.2024.1440309. eCollection 2024.
Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.
铁死亡是近年来提出的一种新型程序性细胞死亡，其主要特征是活性氧和铁介导的脂质过氧化，与程序性细胞死亡（如细胞凋亡、坏死和自噬）不同。铁死亡与多种生理和病理生理过程有关。最近的研究表明，铁死亡可以通过靶向肿瘤、缺血性器官损伤和其他与脂质过氧化相关的退行性疾病中的代谢途径和信号通路来加重或减轻疾病的发生和发展。越来越多的证据表明，铁死亡与各种眼部疾病的发病和进展密切相关，包括角膜损伤、青光眼、年龄相关性黄斑变性、糖尿病性视网膜病变、视网膜脱离和视网膜母细胞瘤。我们对眼部疾病中铁死亡的研究进行综述，揭示了我们对这些疾病发病机制、病因和治疗的理解的重大进展。
