Tan Chee Wah, Zhu Feng, Chia Wan Ni, Young Barnaby E, Yeoh Aileen Ying Yan, Althaus Thomas, Yung Chee Fu, Yap Wee Chee, Lim Beng Lee, Chen Mark I-C, Zhang Jinyan, Mah Yun Yan, Voiglio Eric, Sigal Alex, Huo Jianxin, Xu Shengli, Tan Yee Joo, Lam Kong-Peng, Lye David, Wang Lin-Fa
Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.
National Center of Infectious Diseases, Singapore.
Hlife. 2023 Nov;1(1):26-34. doi: 10.1016/j.hlife.2023.07.002. Epub 2023 Jul 24.
Multiple Omicron sub-lineages have emerged, with Omicron XBB and XBB.1.5 subvariants becoming the dominant variants globally at the time of this study. The key feature of new variants is their ability to escape humoral immunity despite the fact that there are limited genetic changes from their preceding variants. This raises the question of whether Omicron should be regarded as a separate serotype from viruses serologically clustered with the ancestral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Here, we present cross-neutralization data based on a pseudovirus neutralization test using convalescent sera from naïve individuals who had recovered from primary infection by SARS-CoV-1 and SARS-CoV-2 strains/variants including the ancestral virus and variants Beta, Delta, Omicron BA.1, Omicron BA.2 and Omicron BA.5. The results revealed no significant cross-neutralization in any of the three-way testing for SARS-CoV-1, ancestral SARS-CoV-2 and SARS-CoV-2 Omicron subvariants. The data argue for the assignment of three distinct serotypes for the currently known human-infecting SARS-related coronaviruses.
多种奥密克戎亚谱系已经出现，在本研究开展时，奥密克戎XBB和XBB.1.5亚变体已成为全球主要变体。新变体的关键特征是，尽管与之前的变体相比基因变化有限，但它们仍有能力逃避体液免疫。这就引出了一个问题，即奥密克戎是否应被视为与血清学上聚类于原始严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒的病毒属于不同的血清型。在此，我们基于假病毒中和试验展示了交叉中和数据，该试验使用的是初次感染SARS-CoV-1和SARS-CoV-2毒株/变体（包括原始病毒以及贝塔、德尔塔、奥密克戎BA.1、奥密克戎BA.2和奥密克戎BA.5变体）后康复的未接触过其他病原体个体的恢复期血清。结果显示，在针对SARS-CoV-1、原始SARS-CoV-2和SARS-CoV-2奥密克戎亚变体的任何三方测试中均未发现显著的交叉中和现象。这些数据支持为目前已知的感染人类的SARS相关冠状病毒划分三种不同血清型。
