文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

奥密克戎 BA.4 和 BA.5 对疫苗和 BA.1 血清的抗体逃逸。

Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum.

机构信息

Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.

出版信息

Cell. 2022 Jul 7;185(14):2422-2433.e13. doi: 10.1016/j.cell.2022.06.005. Epub 2022 Jun 9.

DOI:10.1016/j.cell.2022.06.005
PMID:35772405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9181312/
Abstract

The Omicron lineage of SARS-CoV-2, which was first described in November 2021, spread rapidly to become globally dominant and has split into a number of sublineages. BA.1 dominated the initial wave but has been replaced by BA.2 in many countries. Recent sequencing from South Africa's Gauteng region uncovered two new sublineages, BA.4 and BA.5, which are taking over locally, driving a new wave. BA.4 and BA.5 contain identical spike sequences, and although closely related to BA.2, they contain further mutations in the receptor-binding domain of their spikes. Here, we study the neutralization of BA.4/5 using a range of vaccine and naturally immune serum and panels of monoclonal antibodies. BA.4/5 shows reduced neutralization by the serum from individuals vaccinated with triple doses of AstraZeneca or Pfizer vaccine compared with BA.1 and BA.2. Furthermore, using the serum from BA.1 vaccine breakthrough infections, there are, likewise, significant reductions in the neutralization of BA.4/5, raising the possibility of repeat Omicron infections.

摘要

新冠病毒奥密克戎变异株于 2021 年 11 月首次被描述，其迅速传播并在全球范围内占据主导地位，并分裂成若干亚系。BA.1 主导了最初的浪潮，但在许多国家已被 BA.2 取代。最近在南非豪登省的测序发现了两种新的亚系 BA.4 和 BA.5，它们正在当地传播，引发了新的浪潮。BA.4 和 BA.5 含有相同的刺突序列，虽然与 BA.2 密切相关，但它们在刺突的受体结合域中含有进一步的突变。在这里，我们使用一系列疫苗和自然免疫血清以及单克隆抗体面板研究了对 BA.4/5 的中和作用。与 BA.1 和 BA.2 相比，接种三剂阿斯利康或辉瑞疫苗的个体血清对 BA.4/5 的中和作用降低。此外，使用 BA.1 疫苗突破性感染的血清，对 BA.4/5 的中和作用也显著降低，这增加了重复感染奥密克戎的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/c9190d534fe2/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/ea420c3f4fdc/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/025c27369d9e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/2627121a0a0b/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/8332d62ca28b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/f20c338029e8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/8d7e60fc7846/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/4d525db391a7/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/f24650d444bd/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/e4859c16f75f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/97cb0ddffd10/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/f94bbe0a8e9c/figs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/68e61f69bc4d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/c9190d534fe2/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/ea420c3f4fdc/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/025c27369d9e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/2627121a0a0b/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/8332d62ca28b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/f20c338029e8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/8d7e60fc7846/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/4d525db391a7/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/f24650d444bd/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/e4859c16f75f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/97cb0ddffd10/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/f94bbe0a8e9c/figs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/68e61f69bc4d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9da/9608062/c9190d534fe2/gr7.jpg

相似文献

[1]
Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum.

Cell. 2022-7-7

[2]
Emerging Variants of SARS-CoV-2 and Novel Therapeutics Against Coronavirus (COVID-19)

2025-1

[3]
Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection.

Emerg Microbes Infect. 2022-12

[4]
SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns.

Cell Host Microbe. 2022-9-14

[5]
Enhancing Omicron Sublineage Neutralization: Insights From Bivalent and Monovalent COVID-19 Booster Vaccines and Recent SARS-CoV-2 Omicron Variant Infections.

Influenza Other Respir Viruses. 2024-10

[6]
Vaccination and Omicron BA.1/BA.2 Convalescence Enhance Systemic but Not Mucosal Immunity against BA.4/5.

Microbiol Spectr. 2023-6-15

[7]
Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice.

Sci Immunol. 2022-12-23

[8]
Pre-Omicron Vaccine Breakthrough Infection Induces Superior Cross-Neutralization against SARS-CoV-2 Omicron BA.1 Compared to Infection Alone.

Int J Mol Sci. 2022-7-12

[9]
Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.5.

Sci Immunol. 2022-11-25

[10]
Different Neutralization Profiles After Primary SARS-CoV-2 Omicron BA.1 and BA.2 Infections.

Front Immunol. 2022

引用本文的文献

[1]
SARS-CoV-2 RBD Scaffolded by AP205 or TIP60 Nanoparticles and Delivered as mRNA Elicits Robust Neutralizing Antibody Responses.

Vaccines (Basel). 2025-7-22

[2]
-alkyl and -benzyl indoles are anti-SARS-CoV-2 agents and nsp13 inhibitors.

J Enzyme Inhib Med Chem. 2025-8-7

[3]
Neutralizing antibody response to Omicron subvariants BA.1 and BA.5 in children and adolescents following the two-dose CoronaVac protocol (Immunita-002, Brazil): a 12-month longitudinal study.

Front Immunol. 2025-7-15

[4]
From Delta to Omicron-Genetic Epidemiology of SARS-CoV-2 (hCoV-19) in Southern Poland.

Pathogens. 2025-7-17

[5]
A Critical Review of the CRISPR-Cas Technology in the Detection of SARS-CoV-2 Variants.

Can J Infect Dis Med Microbiol. 2025-7-9

[6]
Safety, tolerability, and pharmacokinetics of anti-SARS-CoV-2 monoclonal antibody SA55 injection in healthy participants.

Antimicrob Agents Chemother. 2025-8-6

[7]
Viral evolution prediction identifies broadly neutralizing antibodies to existing and prospective SARS-CoV-2 variants.

Nat Microbiol. 2025-6-10

[8]
Predicting high-fitness viral protein variants with Bayesian active learning and biophysics.

Proc Natl Acad Sci U S A. 2025-6-17

[9]
Unveiling protection: a meta-analysis of tixagevimab-cilgavimab prophylaxis in 28,950 transplant recipients and immunocompromised patients against COVID-19.

Virol J. 2025-6-2

[10]
The presence of neutralizing antibodies against omicron subvariants among a vaccinated cohort at one year after the first dose of vaccination in Malaysia.

Sci Rep. 2025-6-1

本文引用的文献

[1]
A broad and potent neutralization epitope in SARS-related coronaviruses.

Proc Natl Acad Sci U S A. 2022-7-19

[2]
Potent cross-reactive antibodies following Omicron breakthrough in vaccinees.

Cell. 2022-6-9

[3]
SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape.

Cell Host Microbe. 2022-2-9

[4]
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.

Cell. 2022-2-3

[5]
Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement.

Science. 2022-2-25

[6]
Omicron severity: milder but not mild.

Lancet. 2022-1-29

[7]
Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization.

Nature. 2022-2

[8]
The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants.

Cell Host Microbe. 2022-1-12

[9]
Production, Titration, Neutralisation, Storage and Lyophilisation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Lentiviral Pseudotypes.

Bio Protoc. 2021-11-5

[10]
Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail.

Nat Microbiol. 2021-10

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索