The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Mol Med Rep. 2024 Sep;30(3). doi: 10.3892/mmr.2024.13285. Epub 2024 Jul 12.
Cordycepin is a nucleoside molecule found in and can be obtained through chemical synthesis and biotransformation. Cordycepin has been extensively studied and has been shown to have antitumour activity. This activity includes effects on the autophagy process and inhibition of the MAPK/ERK and Hedgehog pathways. Ultimately, the inhibitory effect of cordycepin on tumour cells is due to the interplay of these effects. Cordycepin was shown to enhance the therapeutic effects of radiotherapy. There is increasing evidence indicating that cordycepin plays an anticancer role in the treatment of various cancers. The present review aims to provide a clear understanding of the antitumour mechanisms of cordycepin and discuss its present application in the treatment of tumours. This information can be an important theoretical basis and provide clinical guidance for the further development of cordycepin as an antitumour drug.
蛹虫草素是一种核苷分子，存在于蛹虫草中，可以通过化学合成和生物转化获得。蛹虫草素已被广泛研究，具有抗肿瘤活性。这种活性包括对自噬过程的影响以及对 MAPK/ERK 和 Hedgehog 通路的抑制作用。最终，蛹虫草素对肿瘤细胞的抑制作用是由于这些作用的相互作用。蛹虫草素被证明可以增强放射治疗的疗效。越来越多的证据表明，蛹虫草素在治疗各种癌症中具有抗癌作用。本综述旨在阐明蛹虫草素的抗肿瘤机制，并讨论其在肿瘤治疗中的应用。这些信息可以为进一步开发蛹虫草素作为抗肿瘤药物提供重要的理论基础和临床指导。
