Clinical Department of Toxicology and Cardiology, Toxicology Clinic, Stefan Wyszyński Regional Specialist Hospital, Medical University of Lublin, 20-718 Lublin, Poland.
Department of Pharmacology, Medical University of Lublin, Radziwiłłowska 11 Street, 20-080 Lublin, Poland.
Cells. 2024 Jul 6;13(13):1151. doi: 10.3390/cells13131151.
Doxorubicin (DOX) is an anthracycline anticancer agent that is highly effective in the treatment of solid tumors. Given the multiplicity of mechanisms involved in doxorubicin-induced cardiotoxicity, it is difficult to identify a precise molecular target for toxicity. The findings of a literature review suggest that natural products may offer cardioprotective benefits against doxorubicin-induced cardiotoxicity, both in vitro and in vivo. However, further confirmatory studies are required to substantiate this claim. It is of the utmost importance to direct greater attention towards the intricate signaling networks that are of paramount importance for the survival and dysfunction of cardiomyocytes. Notwithstanding encouraging progress made in preclinical studies of natural products for the prevention of DOX-induced cardiotoxicity, these have not yet been translated for clinical use. One of the most significant obstacles hindering the development of cardioprotective adjuvants based on natural products is the lack of adequate bioavailability in humans. This review presents an overview of current knowledge on doxorubicin DOX-induced cardiotoxicity, with a focus on the potential benefits of natural compounds and herbal preparations in preventing this adverse effect. As literature search engines, the browsers in the Scopus, PubMed, Web of Science databases and the ClinicalTrials.gov register were used.
多柔比星（DOX）是一种蒽环类抗癌药物，在治疗实体瘤方面非常有效。鉴于多柔比星诱导的心脏毒性涉及多种机制，因此很难确定毒性的确切分子靶点。文献综述的结果表明，天然产物可能在体外和体内提供对多柔比星诱导的心脏毒性的心脏保护作用。然而，需要进一步的确认性研究来证实这一说法。至关重要的是，要更加关注对心肌细胞的存活和功能障碍至关重要的复杂信号网络。尽管在预防多柔比星诱导的心脏毒性的天然产物的临床前研究中取得了令人鼓舞的进展，但这些研究尚未转化为临床应用。阻碍基于天然产物的心脏保护佐剂发展的最大障碍之一是其在人体中的生物利用度不足。本文综述了当前关于多柔比星 DOX 诱导的心脏毒性的知识，重点介绍了天然化合物和草药制剂在预防这种不良反应方面的潜在益处。文献检索使用了 Scopus、PubMed、Web of Science 数据库中的浏览器和 ClinicalTrials.gov 注册中心。
