可见光促进的3-烯丙基-2-芳基喹唑啉酮的自由基级联环化反应用于合成磷酸化二氢异喹啉并[1,2-]喹唑啉酮。
Visible-light promoted radical cascade cyclization of 3-allyl-2-arylquinazolinones for the synthesis of phosphorylated dihydroisoquinolino[1,2-]quinazolinones.
作者信息
Huang Jun, Ban Caijin, Qin Jiangping, Xu Jiali, Gu Yunqiong, Wei Liang, Yuan Jing-Mei, Huang Guobao
机构信息
Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, College of Chemistry and Materials, Nanning Normal University, Nanning 530001, P. R. China.
Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, Yulin 537000, P. R. China.
出版信息
Chem Commun (Camb). 2024 Jul 30;60(62):8119-8122. doi: 10.1039/d4cc02915a.
A novel visible-light promoted metal-free radical cascade cyclization reaction has been developed with 3-allyl-2-arylquinazolinones as a new class of radical acceptor. This photocatalytic protocol represents an efficient approach to construct phosphorylated dihydroisoquinolino[1,2-]quinazolinones featuring mild conditions, broad substrate scope, and gram-scale synthesis.
以3-烯丙基-2-芳基喹唑啉酮作为一类新型的自由基受体，开发了一种新型可见光促进的无金属自由基级联环化反应。这种光催化方法是构建磷酸化二氢异喹啉并[1,2 -]喹唑啉酮的有效途径，具有反应条件温和、底物范围广和克级规模合成的特点。
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