Department of Internal Medicine, Division of Nephrology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
Department of Internal Medicine, Division of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
Saudi J Kidney Dis Transpl. 2023 Sep 1;34(5):406-415. doi: 10.4103/1319-2442.397202. Epub 2024 Mar 11.
Fabry disease (FD) is associated with inflammation, proteinuria, and chronic kidney disease. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) plays an important role in inflammation in diabetic nephropathy and lupus nephritis. Since there is a close relationship linking serum TWEAK (sTWEAK), inflammation, and carotid intima-media thickness (CIMT) in various kidney diseases, we aimed to determine the relationship between sTWEAK levels and CIMT in subjects with and without proteinuria in a cross-sectional study involving 15 FD patients (seven females, eight males) and seven healthy controls (four females, three males). There were no differences in age, sex, estimated glomerular filtration rate, and biochemical parameters (serum glucose, albumin, creatinine, uric acid, C-reactive protein (CRP), low-density lipoprotein, and high-density lipoprotein) between FD patients and healthy controls. The spot urine protein-creatinine ratios of healthy controls and FD patients were 90 mg/g and 185 mg/g, respectively (P = 0.022). STWEAK levels were higher in FD patients than in healthy controls (P = 0.007). The CIMT of FD patients and healthy controls was 0.55 ± 0.14 mm and 0.42 ± 0.04 mm, respectively (P = 0.007). STWEAK was positively correlated with CRP and CIMT, and negatively with proteinuria (P = 0.005, P = 0.013, and P = 0.018, respectively). In the multivariate analysis, only sTWEAK was an independent variable of increased CIMT. We demonstrated that sTWEAK and CIMT were increased in FD patients. STWEAK might have a role in the pathogenesis of subclinical atherosclerosis in FD.
法布里病（FD）与炎症、蛋白尿和慢性肾脏病有关。肿瘤坏死因子样凋亡弱诱导物（TWEAK）在糖尿病肾病和狼疮性肾炎的炎症中发挥重要作用。由于血清 TWEAK（sTWEAK）、炎症和颈动脉内膜中层厚度（CIMT）在各种肾脏疾病之间存在密切关系，我们旨在确定在一项横断面研究中，有无蛋白尿的 FD 患者（7 名女性，8 名男性）和 7 名健康对照者（4 名女性，3 名男性）之间 sTWEAK 水平与 CIMT 的关系。FD 患者和健康对照组之间的年龄、性别、估计肾小球滤过率和生化参数（血清葡萄糖、白蛋白、肌酐、尿酸、C 反应蛋白（CRP）、低密度脂蛋白和高密度脂蛋白）无差异。健康对照者和 FD 患者的尿蛋白/肌酐比值分别为 90mg/g 和 185mg/g（P=0.022）。FD 患者的 sTWEAK 水平高于健康对照组（P=0.007）。FD 患者和健康对照组的 CIMT 分别为 0.55±0.14mm 和 0.42±0.04mm（P=0.007）。sTWEAK 与 CRP 和 CIMT 呈正相关，与蛋白尿呈负相关（P=0.005，P=0.013，P=0.018）。在多元分析中，只有 sTWEAK 是 CIMT 增加的独立变量。我们证明 FD 患者的 sTWEAK 和 CIMT 增加。sTWEAK 可能在 FD 的亚临床动脉粥样硬化发病机制中起作用。
