Department of Musculoskeletal Oncology and Rehabilitation, National Cancer Center Hospital, 5-1-1, Chuo-Ku, Tokyo, Japan.
Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga, Japan.
Int J Clin Oncol. 2024 Sep;29(9):1391-1397. doi: 10.1007/s10147-024-02557-5. Epub 2024 Jul 12.
Serum level of tartrate-resistant acid phosphatase 5b (TRACP5b) is an excellent serum marker of bone resorption. In patients with giant cell tumor of bone (GCTB), TRACP5b levels are reportedly elevated. This study investigated whether TRACP5b could be a diagnostic serum marker and be useful for detecting postoperative disease progression for GCTB.
Cohort 1: We abstracted data from 120 patients with TRACP5b measurements from our database: 49 patients with GCTB and 71 patients non-GCTB. We compared serum TRACP5b values between the GCTB and non-GCTB groups. Cohort 2 included 47 patients with GCTB who had more than 6 months of follow-up and multiple TRACP5b values. For patients with local recurrence, TRACP5b change rate was calculated by comparing the TRACP5b value just before progression (a) with the value at the time of progression (b): Change rate = [(b)-(a)]/(a). In the non-progression group, the change rate was calculated from the two consecutive TRACP5b values, (c) and (d): Change rate =[(c)-(d)]/(c). We compared TRACP5b change rates between the progression and non-progression groups.
Cohort 1: The GCTB group had a significantly higher mean TRACP5b value (1756 ± 2021 mU/dL) than the non-GCTB group (415 ± 219 mU/dL) (p < 0.0001). Cohort 2: The mean TRACP5b change rate of the progression group was significantly higher than the non-progression group (8.53 ± 8.52 and 0.24 ± 0.27, respectively; p < 0.0001).
TRACP5b is a useful diagnostic marker in GCTB. The rate of change in serum TRACP5b values is a highly sensitive marker for predicting local recurrence in GCTB.
抗酒石酸酸性磷酸酶 5b（TRACP5b）的血清水平是骨吸收的一个极好的血清标志物。据报道，在骨巨细胞瘤（GCTB）患者中，TRACP5b 水平升高。本研究旨在探讨 TRACP5b 是否可以作为一种诊断性血清标志物，用于检测 GCTB 的术后疾病进展。
队列 1：我们从我们的数据库中提取了 120 例接受 TRACP5b 测量的患者的数据：49 例 GCTB 患者和 71 例非 GCTB 患者。我们比较了 GCTB 组和非 GCTB 组之间的血清 TRACP5b 值。队列 2 包括 47 例 GCTB 患者，这些患者的随访时间超过 6 个月，且有多个 TRACP5b 值。对于局部复发的患者，通过比较进展前（a）和进展时（b）的 TRACP5b 值来计算 TRACP5b 变化率：变化率=（b）-（a）/（a）。在非进展组中，通过连续两次 TRACP5b 值（c）和（d）计算变化率：变化率=（c）-（d）/（c）。我们比较了进展组和非进展组之间的 TRACP5b 变化率。
队列 1：GCTB 组的平均 TRACP5b 值（1756±2021 mU/dL）显著高于非 GCTB 组（415±219 mU/dL）（p<0.0001）。队列 2：进展组的平均 TRACP5b 变化率明显高于非进展组（8.53±8.52 和 0.24±0.27，分别；p<0.0001）。
TRACP5b 是 GCTB 的一种有用的诊断标志物。血清 TRACP5b 值的变化率是预测 GCTB 局部复发的一种高度敏感的标志物。
