Yuan Yalin, Zou Mi, Wu Shuqin, Liu Congcong, Hao Liang
Department of Orthopedics, Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
The Second Clinical Medical College, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Hum Cell. 2024 Sep;37(5):1290-1305. doi: 10.1007/s13577-024-01102-w. Epub 2024 Jul 12.
Osteonecrosis of the femoral head (ONFH) is a condition that causes considerable pain and discomfort for patients, and its pathogenic mechanisms are not yet fully understood. While there have been many studies that suggest multiple factors may contribute to its development, current treatments involve both surgical and nonsurgical options. However, there is still much room for improvement in these treatment methods, particularly when it comes to preventing postoperative complications and optimizing surgical procedures. Nanomaterials, as a type of small molecule material, have shown great promise in treating bone tissue diseases, including ONFH. In fact, several nanocomposite materials have demonstrated specific effects in preventing ONFH, promoting bone tissue repair and growth, and optimizing surgical treatment. This article provides a comprehensive overview of current treatments for ONFH, including their advantages and limitations, and reviews the latest advances in nanomaterials for treating this condition. Additionally, this article explores the therapeutic mechanisms involved in using nanomaterials to treat ONFH and to identify new methods and ideas for improving outcomes for patients.
股骨头坏死（ONFH）是一种给患者带来相当大疼痛和不适的病症，其发病机制尚未完全明确。虽然有许多研究表明多种因素可能导致其发生发展，但目前的治疗方法包括手术和非手术选择。然而，这些治疗方法仍有很大的改进空间，特别是在预防术后并发症和优化手术程序方面。纳米材料作为一种小分子材料，在治疗包括ONFH在内的骨组织疾病方面显示出巨大潜力。事实上，几种纳米复合材料在预防ONFH、促进骨组织修复和生长以及优化手术治疗方面已展现出特定效果。本文全面概述了目前ONFH的治疗方法，包括其优缺点，并综述了纳米材料治疗该病症的最新进展。此外，本文探讨了使用纳米材料治疗ONFH所涉及的治疗机制，以确定改善患者治疗效果的新方法和新思路。
