Levine D H
Dev Pharmacol Ther. 1985;8(5):284-91. doi: 10.1159/000457051.
To isolate and demonstrate the effect of insulin on pulmonary surfactant in vivo, islet cell hyperplasia and hyperinsulinemia were produced in fetal rabbits by the litter reduction technique without concomitant hormonal or metabolic changes in mother or fetus. This produced fetuses which were heavier than controls (37.1 vs. 31.5 g), with two-fold higher insulin levels (48.1 vs. 24.3 microU/ml). The fetal weight correlated directly with the insulin level, while the L/S ratio was found to correlate inversely with the insulin level. This inhibitory effect may be mediated by any of several mechanisms which await further investigation.
为了在体内分离并证明胰岛素对肺表面活性物质的作用，通过减少同窝仔兔数量的技术使胎兔出现胰岛细胞增生和高胰岛素血症，同时母体或胎儿未伴随激素或代谢变化。这使得胎兔比对照组更重（37.1克对31.5克），胰岛素水平高出两倍（48.1微单位/毫升对24.3微单位/毫升）。胎儿体重与胰岛素水平直接相关，而L/S比值与胰岛素水平呈负相关。这种抑制作用可能由几种机制中的任何一种介导，有待进一步研究。
