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应用事件相关电位预测记忆障碍门诊患者的淀粉样 PET 状态。

The Use of Event Related Potentials to Predict Amyloid PET Status Among Patients from a Memory Disorders Clinic.

机构信息

Center for Translational Cognitive Neuroscience, VA Boston Healthcare System, Boston, MA, USA.

Department of Behavioral Neuroscience, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, Boston, MA, USA.

出版信息

J Alzheimers Dis. 2024;100(4):1195-1208. doi: 10.3233/JAD-231038.

DOI:10.3233/JAD-231038
PMID:38995774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11380249/
Abstract

BACKGROUND

Amyloid positron emission tomography (PET) scans provide in vivo evidence of Alzheimer's disease (AD); however, their high cost limits their use in standard clinical care. Event related potentials (ERPs) may represent an inexpensive and non-invasive additional method for detecting AD pathology.

OBJECTIVE

We investigated whether ERPs, along with neuropsychological data, serve as predictors of amyloid PET status in patients with memory complaints.

METHODS

Veterans aged 50-100 were recruited from a memory disorders clinic. Participants underwent a neuropsychological battery and an ERP auditory oddball protocol. Twenty-eight patients had a positive amyloid PET scan, and thirty-nine patients had a negative scan.

RESULTS

ERP-P200 target amplitude and P200 standard latency were predictors of amyloid PET status. When submitting to ROC analysis, P200 standard latency exhibited the highest specificity and sensitivity in predicting amyloid PET positivity, correctly classifying the amyloid PET status for 86% of patients.

CONCLUSIONS

ERP-P200 measures are strong indicators of amyloid-β presence in patients from a memory disorder clinic. Increased P200 amplitude and decreased P200 latency in patients with a positive amyloid PET scan may be attributed to hyperactivation of perceptual bottom-up processes compensating for AD-related synaptic loss in the fronto-parietal networks.

摘要

背景

淀粉样蛋白正电子发射断层扫描（PET）为阿尔茨海默病（AD）提供了体内证据；然而，其高昂的成本限制了其在标准临床护理中的应用。事件相关电位（ERPs）可能是一种廉价且非侵入性的额外方法，用于检测 AD 病理学。

目的

我们研究了 ERPs 是否与神经心理学数据一起，作为有记忆主诉的患者淀粉样蛋白 PET 状态的预测因子。

方法

从记忆障碍诊所招募了年龄在 50-100 岁的退伍军人。参与者接受了神经心理学测试和听觉Oddball ERP 测试。28 名患者的淀粉样蛋白 PET 扫描呈阳性，39 名患者的扫描呈阴性。

结果

ERP-P200 目标振幅和 P200 标准潜伏期是淀粉样蛋白 PET 状态的预测因子。当提交给 ROC 分析时，P200 标准潜伏期在预测淀粉样蛋白 PET 阳性方面表现出最高的特异性和敏感性，正确分类了 86%的患者的淀粉样蛋白 PET 状态。

结论

ERP-P200 测量值是记忆障碍诊所患者淀粉样蛋白-β存在的有力指标。正电子发射断层扫描阳性患者的 P200 振幅增加和 P200 潜伏期缩短可能归因于感知自下而上过程的过度激活，以补偿额顶叶网络中 AD 相关的突触丧失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af9a/11380249/2ec5561dbdd9/jad-100-jad231038-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af9a/11380249/f72869f541f8/jad-100-jad231038-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af9a/11380249/48d3cea39fc8/jad-100-jad231038-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af9a/11380249/74a29cd07bd4/jad-100-jad231038-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af9a/11380249/2ec5561dbdd9/jad-100-jad231038-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af9a/11380249/f72869f541f8/jad-100-jad231038-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af9a/11380249/48d3cea39fc8/jad-100-jad231038-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af9a/11380249/74a29cd07bd4/jad-100-jad231038-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af9a/11380249/2ec5561dbdd9/jad-100-jad231038-g004.jpg

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