Department of Oncology Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Department of Radiotherapy, Oncology Department, The First Affiliated Hospital of Xi 'an Jiaotong University, Xi'an, Shaanxi, China.
PLoS One. 2024 Jul 12;19(7):e0306909. doi: 10.1371/journal.pone.0306909. eCollection 2024.
Patients with cancer often present with a hypercoagulable state, which is closely associated with tumor progression. The purpose of this study was to assess the diagnostic efficacy of D-dimer in predicting distant metastasis in colorectal cancer (CRC).
This study included 529 patients diagnosed with CRC at our hospital between January 2020 and December 2022. Plasma coagulation indicators and tumor markers were collected prior to treatment and their diagnostic efficacy for predicting CRC metastasis was assessed by receiver operating characteristic (ROC) curves. Independent risk factors for evaluating tumor metastasis were obtained by multivariate logistic regression analysis.
The level of D-dimer in the metastatic group was significantly higher than that in the non-metastatic group (P<0.001). The results of the multiple logistic regression analysis indicated that lower level of prealbumin and platelet, and higher level of glucose, CEA and D-dimer were independent risk factors for distant metastasis in patients with CRC (P<0.05, respectively). The combination of prealbumin, glucose, D-dimer, platelet and tumor markers (PRE2) was found to be significantly more effective in predicting metastasis of CRC when compared to the combination of tumor marker alone (PRE1, P<0.001).
Plasma D-dimer may be a novel tumor marker for screening metastases of CRC.
癌症患者常表现出高凝状态，这与肿瘤进展密切相关。本研究旨在评估 D-二聚体在预测结直肠癌（CRC）远处转移中的诊断效能。
本研究纳入了 2020 年 1 月至 2022 年 12 月在我院诊断为 CRC 的 529 例患者。在治疗前收集了血浆凝血指标和肿瘤标志物，并通过受试者工作特征（ROC）曲线评估其对 CRC 转移的诊断效能。采用多因素 logistic 回归分析获得评估肿瘤转移的独立危险因素。
转移组的 D-二聚体水平明显高于非转移组（P<0.001）。多因素 logistic 回归分析结果表明，低白蛋白、血小板水平和高血糖、CEA、D-二聚体水平是 CRC 患者远处转移的独立危险因素（P<0.05，分别）。与单独使用肿瘤标志物（PRE1）相比，白蛋白、葡萄糖、D-二聚体、血小板和肿瘤标志物的联合（PRE2）在预测 CRC 转移方面更有效（P<0.001）。
血浆 D-二聚体可能是筛查 CRC 转移的新型肿瘤标志物。
