MINES Paris, PSL University, Center for Materials Forming (CEMEF), UMR CNRS 7635, CS 10207, 06904 Sophia Antipolis, France.
MINES Paris, PSL University, Center for Materials Forming (CEMEF), UMR CNRS 7635, CS 10207, 06904 Sophia Antipolis, France.
Biomater Adv. 2024 Oct;163:213954. doi: 10.1016/j.bioadv.2024.213954. Epub 2024 Jul 6.
The release of the model drug theophylline from silica-pectin aerogels was investigated. The composite aerogels were prepared via impregnation of pectin alcogels with silica sol, followed by in situ silica gelation and drying with supercritical CO. The structural and physico-chemical properties of the aerogels were tuned via the preparation conditions (type of silica sol, calcium crosslinking of pectin or not). Theophylline was loaded via impregnation and its release into simulated gastric fluid was studied during 1 h followed by release into simulated intestinal fluid. The swelling, mass loss and theophylline release behavior of the composites were analyzed and correlated with material properties. It followed that only aerogels prepared with calcium-crosslinked pectin and polyethoxydisiloxane were stable in aqueous systems, exhibiting a slow theophylline release governed by near-Fickian diffusion.
研究了茶碱从硅-果胶气凝胶中的释放。通过将果胶醇凝胶浸渍在硅溶胶中，然后进行原位硅胶化并用超临界 CO2干燥来制备复合气凝胶。通过制备条件（硅溶胶的类型、果胶的钙交联或不交联）来调节气凝胶的结构和物理化学性质。通过浸渍将茶碱负载，并在 1 小时内研究其在模拟胃液中的释放，然后在模拟肠液中释放。分析了复合材料的溶胀、质量损失和茶碱释放行为，并与材料特性相关联。结果表明，只有用钙交联果胶和聚乙氧基二硅氧烷制备的气凝胶在水体系中稳定，表现出由近菲克扩散控制的缓慢茶碱释放。
