General Practice / Family Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Division of Preventive Medicine, School of Medicine, UC San Diego, San Diego, CA, USA.
Sci Rep. 2024 Jul 12;14(1):16114. doi: 10.1038/s41598-024-66948-4.
Information on the associations of testosterone levels with abdominal muscle volume and density in men is limited, while the role of estradiol and SHBG on these muscle characteristics are unclear. Therefore, this study aimed to investigate the association between fasting serum sex hormones and CT-derived abdominal muscle area and radiodensity in adult men. Conducted as a cross sectional observational study using data from the Multi-Ethnic Study of Atherosclerosis, our analyses focused on a community-based sample of 907 men aged 45-84 years, with 878 men having complete data. CT scans of the abdomen were interrogated for muscle characteristics, and multivariable linear regressions were used to test the associations. After adjustment for relevant factors, higher levels of both total testosterone and estradiol were associated with higher abdominal muscle area (1.74, 0.1-3.4, and 1.84, 0.4-3.3, respectively). In the final analyses, levels of total testosterone showed a positive association, while an inverse relationship was observed for SHBG with abdominal muscle radiodensity (0.3, 0.0-0.6, and - 0.33, - 0.6 to - 0.1, respectively). Our results indicate a complex association between sex hormones and abdominal muscle characteristics in men. Specifically, total testosterone and estradiol were associated with abdominal muscle area, while only total testosterone was associated with muscle radiodensity and SHBG was inversely associated with muscle radiodensity.Clinical Trial: NCT00005487.
关于睾丸激素水平与男性腹部肌肉量和密度之间的关联的信息有限，而雌二醇和 SHBG 对这些肌肉特征的作用尚不清楚。因此，本研究旨在探讨空腹血清性激素与 CT 衍生的成年男性腹部肌肉面积和密度之间的关系。本研究采用横断面观察性研究，使用动脉粥样硬化多民族研究的数据，我们的分析集中在一个基于社区的 907 名年龄在 45-84 岁的男性样本中，其中 878 名男性有完整的数据。对腹部 CT 扫描进行肌肉特征检查，并使用多变量线性回归检验相关性。在调整了相关因素后，总睾酮和雌二醇水平较高与较高的腹部肌肉面积相关（1.74，0.1-3.4 和 1.84，0.4-3.3）。在最终分析中，总睾酮水平呈正相关，而 SHBG 与腹部肌肉密度呈负相关（0.3，0.0-0.6 和-0.33，-0.6 至-0.1）。我们的研究结果表明，男性的性激素与腹部肌肉特征之间存在复杂的关联。具体来说，总睾酮和雌二醇与腹部肌肉面积相关，而只有总睾酮与肌肉密度相关，SHBG 与肌肉密度呈负相关。临床试验：NCT00005487。
