Papageorgiou Virginia, Ververidis Charalampos, Mylonakis Mathios E, Savvas Ioannis, Kazakos George
Companion Animal Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, 11 Stavrou Voutyra St., 54627 Thessaloniki, Greece.
Animals (Basel). 2024 Jun 21;14(13):1840. doi: 10.3390/ani14131840.
This prospective, randomized study aimed to assess the anxiolytic efficacy of gabapentin or alprazolam in cats during short-term postoperative hospitalization. Sixty cats were randomly assigned to three groups (gabapentin-treated [100 mg per cat], alprazolam-treated [0.125 mg per cat], or placebo-treated), with treatments administered twice daily for two days. Stress levels were evaluated using Cat Stress Scores, serum cortisol, and glucose concentrations. Pain scores, food consumption, and adverse effects such as sedation were also monitored. Fifty-five cats completed the study. Both medications demonstrated similar reductions in stress levels. Cats receiving gabapentin had lower pain scores, while those receiving alprazolam exhibited significantly increased food intake on the first postoperative day. However, both medications resulted in comparable levels of sedation. In the context of postoperative hospitalization, pharmacological intervention with anxiolytics could be effective in reducing stress levels. Despite potential side effects, gabapentin and alprazolam may contribute to an improved quality of short-term hospitalization for cats.
这项前瞻性随机研究旨在评估加巴喷丁或阿普唑仑在猫术后短期住院期间的抗焦虑疗效。60只猫被随机分为三组（加巴喷丁治疗组[每只猫100毫克]、阿普唑仑治疗组[每只猫0.125毫克]或安慰剂治疗组），治疗为期两天，每天给药两次。使用猫应激评分、血清皮质醇和血糖浓度评估应激水平。还监测了疼痛评分、食物摄入量以及诸如镇静等不良反应。55只猫完成了研究。两种药物在降低应激水平方面表现出相似效果。接受加巴喷丁治疗的猫疼痛评分较低，而接受阿普唑仑治疗的猫在术后第一天食物摄入量显著增加。然而，两种药物导致的镇静水平相当。在术后住院的情况下，使用抗焦虑药物进行药理干预可有效降低应激水平。尽管存在潜在副作用，但加巴喷丁和阿普唑仑可能有助于改善猫短期住院的质量。
