García-Álvarez Natalia, Oleaga Álvaro, García-Iglesias María José, Pérez-Martínez Claudia, Fernández Daniel, Álvarez Luis Miguel, Balsera Ramón, Balseiro Ana
Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, 24071 León, Spain.
Sociedad de Servicios del Principado de Asturias S.A. (SERPA), La Laboral, 33203 Gijón, Spain.
Animals (Basel). 2024 Jun 30;14(13):1936. doi: 10.3390/ani14131936.
Reports on neoplasms in bears are scarce, especially concerning ovarian tumors. A large primary ovarian neoplasm with multiple metastasis was found during the necropsy of a 14-year-old free-ranging Eurasian brown bear () from Northwestern Spain. Histopathology and immunohistochemistry allowed for the diagnosis of a sex cord stromal tumor. This is a complex group of neoplasms which differ in the predominant cell morphology and immunohistochemical features. The microscopic examination revealed two types of cells, one with eosinophilic cytoplasm, intermingled with larger vacuolated cells rich in lipids. The evaluation of the immunoreactivity to different markers, frequently used in the characterization of gonadal tumors (INHA, inhibin-alpha; PLAP, placental alkaline phosphatase; Ki-67; α-SMA, actin alpha-smooth muscle) and inflammation patterns (IBA1, ionized calcium-binding adapter molecule for macrophages; CD3 for T lymphocytes; CD20 for B lymphocytes), displayed significant INHA positive immunostaining of neoplastic cells, as well as inflammatory cell infiltration, mainly composed of macrophages and B lymphocytes. These findings were consistent with a malignant ovarian steroid cell tumor, not otherwise specified. The present study characterizes an unusual type of neoplasm, and also represents the first report of an ovarian sex cord stromal tumor in .
关于熊肿瘤的报道很少，尤其是关于卵巢肿瘤的报道。在对一只来自西班牙西北部的14岁野生欧亚棕熊进行尸检时，发现了一个伴有多处转移的大型原发性卵巢肿瘤。组织病理学和免疫组织化学诊断为性索间质肿瘤。这是一组复杂的肿瘤，其主要细胞形态和免疫组织化学特征各不相同。显微镜检查发现两种类型的细胞，一种是嗜酸性细胞质的细胞，与富含脂质的较大空泡化细胞混合在一起。对常用于性腺肿瘤特征化的不同标志物（INHA，抑制素α；PLAP，胎盘碱性磷酸酶；Ki-67；α-SMA，α平滑肌肌动蛋白）以及炎症模式（IBA1，巨噬细胞的离子钙结合衔接分子；CD3用于T淋巴细胞；CD20用于B淋巴细胞）的免疫反应性评估显示，肿瘤细胞有明显的INHA阳性免疫染色，以及炎症细胞浸润，主要由巨噬细胞和B淋巴细胞组成。这些发现与未另行指定的恶性卵巢类固醇细胞瘤一致。本研究描述了一种不寻常的肿瘤类型，也是关于[此处可能缺失具体物种名称]卵巢性索间质肿瘤的首次报道。
