Lin Jing-Ting, Chiang Yi-Chan, Li Po-Hsien, Chiang Po-Yuan
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 40227, Taiwan.
Department of Food and Nutrition, Providence University, Taichung 43301, Taiwan.
Foods. 2024 Jun 26;13(13):2022. doi: 10.3390/foods13132022.
Controlled-release tablets offer several benefits, such as controlled release, odor masking, ease of use, stability, extended shelf life, and reduced production costs. This study developed combined curcumin controlled-release tablets (CCCTs) to increase the bioavailability of curcumin with hydroxypropyl methylcellulose (HPMC), chitosan, and sodium alginate. The hardness of the CCCTs was 5.63-1.98 kgf, friability was 0.00-1.22%, and disintegration time was 0.00-401.25 min. Differential scanning calorimetry and Fourier-transform infrared spectroscopy indicated a high compatibility between the excipients and curcumin. CCCTs with chitosan formed a gel structure, impeded disintegration, and reduced the release rate to 72.5% in simulated gastric fluid. In simulated intestinal fluid, CCCT with the HPMC-sodium alginate group formed a polyelectrolyte membrane hydrogel to prolong release from 6 to 12 h. This study developed various CCCT formulations that can be delivered through the gastric or intestinal tracts, using chitosan and HPMC-sodium alginate as excipients, respectively. CCCT can be used as a reference strategy for controlled-release curcumin delivery in the functional and healthcare supplement development.
控释片具有多种优点，如控释、掩味、使用方便、稳定性好、保质期延长以及生产成本降低等。本研究开发了姜黄素复合控释片（CCCTs），以通过羟丙基甲基纤维素（HPMC）、壳聚糖和海藻酸钠提高姜黄素的生物利用度。CCCTs的硬度为5.63 - 1.98千克力，脆碎度为0.00 - 1.22%，崩解时间为0.00 - 401.25分钟。差示扫描量热法和傅里叶变换红外光谱表明辅料与姜黄素之间具有高度相容性。含壳聚糖的CCCTs形成凝胶结构，阻碍崩解，并使在模拟胃液中的释放率降低至72.5%。在模拟肠液中，HPMC - 海藻酸钠组的CCCT形成聚电解质膜水凝胶，将释放时间从6小时延长至12小时。本研究分别以壳聚糖和HPMC - 海藻酸钠为辅料，开发了多种可通过胃肠道给药的CCCT制剂。CCCT可作为功能性和保健补充剂开发中控释姜黄素递送的参考策略。
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